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Tnfsf10 Gene Detail
Summary
  • Symbol
    Tnfsf10
  • Name
    tumor necrosis factor (ligand) superfamily, member 10
  • Synonyms
    A330042I21Rik, APO-2L, Trail
  • Feature Type
    protein coding gene
  • IDs
    MGI:107414
    NCBI Gene: 22035
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:27371226-27393814 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 10.82 cM, cytoband A3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    169 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107414
 protein coding gene Chr3:27371177-27396576 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027110
 protein coding gene Chr3:24634798-24662172 (+)
A/J MGP_AJ_G0027070
 protein coding gene Chr3:24451240-24474991 (+)
AKR/J MGP_AKRJ_G0027039
 protein coding gene Chr3:24760460-24789754 (+)
BALB/cJ MGP_BALBcJ_G0027082
 protein coding gene Chr3:24126634-24151969 (+)
C3H/HeJ MGP_C3HHeJ_G0026823
 protein coding gene Chr3:24810011-24834708 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027527
 protein coding gene Chr3:26011371-26037615 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024889
 protein coding gene Chr3:22461029-22488130 (+)
CAST/EiJ MGP_CASTEiJ_G0026278
 protein coding gene Chr3:24639222-24664868 (+)
CBA/J MGP_CBAJ_G0026801
 protein coding gene Chr3:26676192-26706121 (+)
DBA/2J MGP_DBA2J_G0026935
 protein coding gene Chr3:24000939-24025600 (+)
FVB/NJ MGP_FVBNJ_G0026903
 protein coding gene Chr3:23472301-23501176 (+)
LP/J MGP_LPJ_G0027047
 protein coding gene Chr3:25312994-25337171 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026924
 protein coding gene Chr3:29263381-29287509 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027587
 protein coding gene Chr3:24471758-24502513 (+)
PWK/PhJ MGP_PWKPhJ_G0026011
 protein coding gene Chr3:23459594-23483644 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025821
 protein coding gene Chr3:24020904-24044749 (+)
WSB/EiJ MGP_WSBEiJ_G0026351
 protein coding gene Chr3:24521322-24554844 (+)



Homology
more
  • Human Ortholog
    TNFSF10, TNF superfamily member 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFSF10, TNF superfamily member 10
  • Synonyms
    Apo-2L, APO2L, CD253, TANCR, TL2, TNLG6A, TRAIL
  • Links
    NCBI Gene ID: 8743
    neXtProt AC: NX_P50591
    UniProt: P50591

  • Chr Location
    3q26.31; chr3:172505508-172523475 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TNFSF10 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 3 alleles in 6 genetic backgrounds
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show thymus hyperplasia, abnormal negative T cell selection, increased susceptibility to autoimmune diseases and to tumor initiation and metastasis, and resistance to induced hepatitis. Homozygotes for another null allele are unable to control A20 lymphoma progression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    60
  • cDNA Data
    24
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22035 NCBI Gene Model | MGI Sequence Detail 22589 C57BL/6J ±  kb
    transcript NM_009425 RefSeq | MGI Sequence Detail 4944 Not Specified  
    polypeptide P50592 UniProt | EBI | MGI Sequence Detail 291 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000002106 tumor necrosis factor ligand superfamily member 10
      (term hierarchy)
    • InterPro Domains
      IPR021184 Tumour necrosis factor, conserved site
      IPR006052 Tumour necrosis factor domain
      IPR017355 Tumour necrosis factor ligand 10/11
      IPR008983 Tumour necrosis factor-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 24

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35883, MGI:2139709
    References
    more
    • Summaries
      All 160
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 11
      Phenotypes 82
    • Earliest
      J:30253 Wiley SR, et al., Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 1995 Dec;3(6):673-82
    • Latest
      J:346029 Krishnan A, et al., Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) deletion in myeloid cells augments cholestatic liver injury. Sci Rep. 2024 Jan 25;14(1):2145
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/30/2024
    MGI 6.23     		The Jackson Laboratory