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Adra1d Gene Detail
Summary
  • Symbol
    Adra1d
  • Name
    adrenergic receptor, alpha 1d
  • Synonyms
    Adra-1, Adra1, Adra1a, alpha1D-AR, Gpcr8
  • Feature Type
    protein coding gene
  • IDs
    MGI:106673
    NCBI Gene: 11550
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:131387770-131404203 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.50 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    573 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106673
 protein coding gene Chr2:131387277-131404417 (-)
129S1/SvImJ ENSMUSG00200043692
 protein coding gene Chr2:128432687-128449153 (-)
A/J ENSMUSG00195026492
 protein coding gene Chr2:128464007-128480443 (-)
AKR/J ENSMUSG00220041354
 protein coding gene Chr2:128226331-128242799 (-)
BALB/cJ ENSMUSG00180044096
 protein coding gene Chr2:128282509-128298944 (-)
C3H/HeJ ENSMUSG00175037252
 protein coding gene Chr2:128816549-128833016 (-)
C57BL/6NJ ENSMUSG00215030137
 protein coding gene Chr2:128312032-128328467 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024330
 protein coding gene Chr2:124332475-124348695 (-)
CAST/EiJ ENSTCUG00005034076
 protein coding gene Chr2:127591351-127607676 (-)
CBA/J ENSMUSG00210031926
 protein coding gene Chr2:128673187-128689658 (-)
DBA/2J ENSMUSG00185031938
 protein coding gene Chr2:128317971-128334302 (-)
FVB/NJ ENSMUSG00205029786
 protein coding gene Chr2:127488285-127504722 (-)
JF1/MsJ ENSUMUG00000025746
 protein coding gene Chr2:128145916-128162375 (-)
LP/J ENSMUSG00230039022
 protein coding gene Chr2:130067806-130084271 (-)
NOD/ShiLtJ ENSMUSG00190014740
 protein coding gene Chr2:128424504-128440932 (-)
NZO/HlLtJ ENSMUSG00225026537
 protein coding gene Chr2:137976639-137993105 (-)
PWK/PhJ ENSLUMG00010042052
 protein coding gene Chr2:128119823-128136163 (-)
SPRET/EiJ ENSMSPG00010023962
 protein coding gene Chr2:130497381-130513891 (-)
WSB/EiJ ENSIUOG00005039786
 protein coding gene Chr2:128244883-128261504 (-)



Homology
more
  • Human Ortholog
    ADRA1D, adrenoceptor alpha 1D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADRA1D, adrenoceptor alpha 1D
  • Synonyms
    ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2
  • Links
    NCBI Gene ID: 146
    UniProt: P25100

  • Chr Location
    20p13; chr20:4220630-4249287 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display hypotension or reduced rearing behavior in a novel environment, decreased wheel-running activity during the night, and reduced hyperlocomotion after amphetamine administration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    616
  • Tissues
    12
  • cDNA Data
    7
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027335 Ensembl Gene Model | MGI Sequence Detail 16434 C57BL/6J ±  kb
    transcript ENSMUST00000103184 Ensembl | MGI Sequence Detail 1899 Not Applicable  
    polypeptide ENSMUSP00000099473 Ensembl | MGI Sequence Detail 562 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 9
      Primer pair 2
      Other 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-1134, MGD-MRK-1139, MGD-MRK-16339, MGD-MRK-28037, MGD-MRK-35132, MGI:104746, MGI:99561
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 24
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:370618 Heo EY, et al., Impaired neuromodulator crosstalk delays arousal-dependent astroglia Ca(2+) activation in mouse models of Alzheimer's disease. iScience. 2025 Aug 15;28(8):113120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory