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Plcb3 Gene Detail
Summary
  • Symbol
    Plcb3
  • Name
    phospholipase C, beta 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:104778
    NCBI Gene: 18797
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6931081-6951738 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.10 cM, cytoband B
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    416 from dbSNP Build 142
  • Strain Annotations
    28
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104778
 protein coding gene Chr19:6929693-6953838 (-)
129S1/SvImJ ENSMUSG00200051163
 protein coding gene Chr19:3656589-3672690 (-)
A/J ENSMUSGG00195055560
 protein coding gene Chr19:4058870-4062503 (-)
A/J ENSMUSG00195050080
 protein coding gene Chr19:4062568-4074499 (-)
AKR/J ENSMUSGG00220054974
 protein coding gene Chr19:3828303-3831936 (-)
AKR/J ENSMUSG00220034126
 protein coding gene Chr19:3832001-3843931 (-)
BALB/cJ ENSMUSG00180046273
 protein coding gene Chr19:4426139-4438072 (-)
BALB/cJ ENSMUSGG00180055645
 protein coding gene Chr19:4422441-4426074 (-)
C3H/HeJ ENSMUSGG00175055197
 protein coding gene Chr19:3678883-3682516 (-)
C3H/HeJ ENSMUSG00175011978
 protein coding gene Chr19:3682581-3694512 (-)
C57BL/6NJ ENSMUSG00215042106
 protein coding gene Chr19:3901085-3913013 (-)
C57BL/6NJ ENSMUSGG00215055860
 protein coding gene Chr19:3897387-3901020 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022621
 protein coding gene Chr19:3622703-3638803 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210055104
 protein coding gene Chr19:3682253-3685886 (-)
CBA/J ENSMUSG00210049600
 protein coding gene Chr19:3685951-3697875 (-)
DBA/2J ENSMUSGG00185058005
 protein coding gene Chr19:4058728-4062361 (-)
DBA/2J ENSMUSG00185047596
 protein coding gene Chr19:4062426-4074350 (-)
FVB/NJ ENSMUSG00205036595
 protein coding gene Chr19:4061479-4073421 (-)
FVB/NJ ENSMUSGG00205054710
 protein coding gene Chr19:4057781-4061414 (-)
JF1/MsJ ENSUMUG00000034323
 protein coding gene Chr19:4018084-4034231 (-)
LP/J ENSMUSG00230053723
 protein coding gene Chr19:4987391-4999321 (-)
LP/J ENSMUSGG00230055932
 protein coding gene Chr19:4983693-4987326 (-)
NOD/ShiLtJ ENSMUSGG00190055165
 protein coding gene Chr19:3590156-3593789 (-)
NOD/ShiLtJ ENSMUSG00190047169
 protein coding gene Chr19:3593854-3605784 (-)
NZO/HlLtJ ENSMUSGG00225055205
 protein coding gene Chr19:8692507-8696140 (-)
NZO/HlLtJ ENSMUSG00225026658
 protein coding gene Chr19:8696205-8708139 (-)
PWK/PhJ ENSLUMG00010007105
 protein coding gene Chr19:3782782-3798959 (-)
SPRET/EiJ ENSMSPG00010050264
 protein coding gene Chr19:3774963-3791140 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PLCB3, phospholipase C beta 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLCB3, phospholipase C beta 3
  • Synonyms
    SMDCD
  • Links
    NCBI Gene ID: 5331
    UniProt: Q01970

  • Chr Location
    11q13.1; chr11:64251514-64269452 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PLCB3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one targeted mutation die at E2.5 and exhibit poor embryonic organization and hypocellularity. Mice homozygous for a second targeted mutation survive to adulthood and exhibit an increased antinocieptive response to opioids.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    75
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    116
  • cDNA Data
    63
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18797 NCBI Gene Model | MGI Sequence Detail 20658 C57BL/6J ±  kb
    transcript NM_008874 RefSeq | MGI Sequence Detail 4273 ZRU/MplStud  
    polypeptide P51432 UniProt | EBI | MGI Sequence Detail 1234 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000012830 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
      (term hierarchy)
    • EC
      3.1.4.11
    • InterPro Domains
      IPR000008 C2 domain
      IPR035892 C2 domain superfamily
      IPR011992 EF-hand domain pair
      IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
      IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
      IPR053945 Phosphoinositide phospholipase C beta 1-4-like, EF-hand domain
      IPR001192 Phosphoinositide phospholipase C family
      IPR014815 Phospholipase C-beta, C-terminal domain
      IPR042531 Phospholipase C-beta, C-terminal domain superfamily
      IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
      IPR037862 PLC-beta, PH domain
      IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
    • GlyGen
      P51432 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 69
      Genomic 1
      cDNA 64
      Primer pair 3
      Other 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28070
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 6
      Gene Ontology 17
      Phenotypes 31
    • Earliest
      J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
    • Latest
      J:386299 Mohamed FA, et al., Biasing G protein betagamma subunit downstream signaling enhances the analgesic effects of endogenous opioid receptor agonists during nitroglycerin-induced thermal hypersensitivity. Mol Pharmacol. 2025 Sep;107(9):100068
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory