About   Help   FAQ
Pomc Gene Detail
Summary
  • Symbol
    Pomc
  • Name
    pro-opiomelanocortin-alpha
  • Synonyms
    ACTH, adrenal corticotropic hormone, alpha-melanocyte stimulating hormone, alpha-MSH, alphaMSH, BE, beta-endorphin, beta-melanocyte stimulating hormone, beta-MSH, gamma-melanocyte stimulating hormone, gamma-MSH, POMC, Pomc-1
Location &
Maps
more
  • Sequence Map
    Chr12:4004951-4010642 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 1.99 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97742
 protein coding gene Chr12:4004945-4010643 (+)
129S1/SvImJ ENSMUSG00200023235
 protein coding gene Chr12:958341-964030 (+)
A/J ENSMUSG00195013665
 protein coding gene Chr12:986014-991707 (+)
AKR/J ENSMUSG00220025836
 protein coding gene Chr12:983586-989271 (+)
BALB/cJ ENSMUSG00180014973
 protein coding gene Chr12:982495-988186 (+)
C3H/HeJ ENSMUSG00175009475
 protein coding gene Chr12:965318-971034 (+)
C57BL/6NJ ENSMUSG00215011616
 protein coding gene Chr12:913151-918843 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017577
 protein coding gene Chr12:745355-751076 (+)
CAST/EiJ ENSTCUG00005021756
 protein coding gene Chr12:782411-788120 (+)
CBA/J ENSMUSG00210013069
 protein coding gene Chr12:985052-990768 (+)
DBA/2J ENSMUSG00185020323
 protein coding gene Chr12:965318-971011 (+)
FVB/NJ ENSMUSG00205002991
 protein coding gene Chr12:762998-768689 (+)
JF1/MsJ ENSUMUG00000027618
 protein coding gene Chr12:948405-954133 (+)
LP/J ENSMUSG00230009538
 protein coding gene Chr12:2793429-2799120 (+)
NOD/ShiLtJ ENSMUSG00190007848
 protein coding gene Chr12:2205123-2210814 (+)
NZO/HlLtJ ENSMUSG00225018627
 protein coding gene Chr12:4851010-4856705 (+)
PWK/PhJ ENSLUMG00010015611
 protein coding gene Chr12:777588-783304 (+)
SPRET/EiJ ENSMSPG00010005028
 protein coding gene Chr12:1173055-1178956 (+)
WSB/EiJ ENSIUOG00005002282
 protein coding gene Chr12:964090-969791 (+)



Homology
more
  • Human Ortholog
    POMC, proopiomelanocortin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POMC, proopiomelanocortin
  • Synonyms
    ACTH, CLIP, LPH, MSH, NPP, OBAIRH, POC
  • Links
    NCBI Gene ID: 5443
    UniProt: P01189

  • Chr Location
    2p23.3; chr2:25160853-25168903 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pomc mouse models; 6 with human POMC associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    67 phenotypes from 6 alleles in 13 genetic backgrounds
    11 phenotypes from multigenic genotypes
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation are obese and exhibit abnormal hormone levels, abnormal pigmentation, increased food intake, and adiposity. Mice homozygous for another knock-out allele exhibit altered reward based behavior and immune response toLPS treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1207
  • Tissues
    288
  • cDNA Data
    79
  • Literature Summary
    214
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020660 Ensembl Gene Model | MGI Sequence Detail 5692 C57BL/6J ±  kb
    transcript ENSMUST00000219543 Ensembl | MGI Sequence Detail 1043 Not Applicable  
    polypeptide ENSMUSP00000151504 Ensembl | MGI Sequence Detail 235 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 127
      Genomic 8
      cDNA 87
      Primer pair 16
      Other 16
      Antibodies 34

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13580, MGD-MRK-13582
    References
    more
    • Summaries
      All 484
      Developmental Gene Expression 214
      Diseases 1
      Gene Ontology 15
      Phenotypes 89
    • Earliest
      J:21792 Civelli O, et al., Detection and quantitation of pro-opiomelanocortin mRNA in pituitary and brain tissues from different species. J Biol Chem. 1982 Jun 25;257(12):6783-7
    • Latest
      J:391100 Gonzalez-Costa T, et al., Systemic and cardiac pathology induced by a clinically relevant USP8 activating mutation. Dis Model Mech. 2026 Jul 1;19(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory