About   Help   FAQ
Drd3 Gene Detail
Summary
  • Symbol
    Drd3
  • Name
    dopamine receptor D3
  • Synonyms
    D3R, D3 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:94925
    NCBI Gene: 13490
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:43574389-43643295 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 28.44 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1492 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94925
 protein coding gene Chr16:43574285-43646353 (+)
129S1/SvImJ ENSMUSG00200026210
 protein coding gene Chr16:40472801-40541728 (+)
A/J ENSMUSG00195010469
 protein coding gene Chr16:40042407-40113110 (+)
AKR/J ENSMUSG00220025542
 protein coding gene Chr16:40381368-40452063 (+)
BALB/cJ ENSMUSG00180013145
 protein coding gene Chr16:40248921-40319638 (+)
C3H/HeJ ENSMUSG00175028415
 protein coding gene Chr16:40528285-40597238 (+)
C57BL/6NJ ENSMUSG00215005633
 protein coding gene Chr16:40354315-40423257 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020757
 protein coding gene Chr16:40626002-40684665 (+)
CAST/EiJ ENSTCUG00005012620
 protein coding gene Chr16:40797444-40859311 (+)
CBA/J ENSMUSG00210027118
 protein coding gene Chr16:40551081-40620009 (+)
DBA/2J ENSMUSG00185024223
 protein coding gene Chr16:40428655-40499369 (+)
FVB/NJ ENSMUSG00205017234
 protein coding gene Chr16:40382747-40451719 (+)
JF1/MsJ ENSUMUG00000017347
 protein coding gene Chr16:40681198-40742178 (+)
LP/J ENSMUSG00230028551
 protein coding gene Chr16:43026045-43094965 (+)
NOD/ShiLtJ ENSMUSG00190017162
 protein coding gene Chr16:40558442-40629129 (+)
NZO/HlLtJ ENSMUSG00225028220
 protein coding gene Chr16:46111973-46180887 (+)
PWK/PhJ ENSLUMG00010027062
 protein coding gene Chr16:40571463-40633318 (+)
SPRET/EiJ ENSMSPG00010006669
 protein coding gene Chr16:40610527-40671206 (+)
WSB/EiJ ENSIUOG00005012853
 protein coding gene Chr16:40668759-40739479 (+)



Homology
more
  • Human Ortholog
    DRD3, dopamine receptor D3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DRD3, dopamine receptor D3
  • Synonyms
    D3DR, ETM1, FET1
  • Links
    NCBI Gene ID: 1814
    UniProt: P35462

  • Chr Location
    3q13.31; chr3:114127580-114199407 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Drd3 mouse models; 3 with human DRD3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 4 alleles in 9 genetic backgrounds
    24 phenotypes from multigenic genotypes
    113 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show exploratory hyperactivity and increased locomotion and rearing behavior, with heterozygous mice displaying similar, but less pronounced, behaviors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    102
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    99
  • cDNA Data
    9
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022705 Ensembl Gene Model | MGI Sequence Detail 68907 C57BL/6J ±  kb
    transcript ENSMUST00000229953 Ensembl | MGI Sequence Detail 1712 Not Applicable  
    polypeptide ENSMUSP00000155033 Ensembl | MGI Sequence Detail 478 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 8
      cDNA 9
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-8898
    References
    more
    • Summaries
      All 189
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 34
      Phenotypes 113
    • Earliest
      J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
    • Latest
      J:372563 Cadeddu R, et al., Tic-related behaviors in Celsr3 mutant mice are contributed by alterations of striatal D(3) dopamine receptors. Mol Psychiatry. 2025 Sep;30(9):3912-3924
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory