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Cyp19a1 Gene Detail
Summary
  • Symbol
    Cyp19a1
  • Name
    cytochrome P450, family 19, subfamily a, polypeptide 1
  • Synonyms
    Ar, ArKO, aromatase, Cyp19, Int-5, Int5, p450arom
  • Feature Type
    protein coding gene
  • IDs
    MGI:88587
    NCBI Gene: 13075
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:54073221-54175394 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 29.49 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2286 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88587
 protein coding gene Chr9:54073221-54175448 (-)
129S1/SvImJ ENSMUSG00200030721
 protein coding gene Chr9:51193956-51221664 (-)
A/J ENSMUSG00195034586
 protein coding gene Chr9:50898554-50926272 (-)
AKR/J ENSMUSG00220028622
 protein coding gene Chr9:51031231-51058791 (-)
BALB/cJ ENSMUSG00180015208
 protein coding gene Chr9:51011913-51039622 (-)
C3H/HeJ ENSMUSG00175019393
 protein coding gene Chr9:51023766-51051479 (-)
C57BL/6NJ ENSMUSG00215017441
 protein coding gene Chr9:51006729-51034292 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032225
 protein coding gene Chr9:50919952-50948008 (-)
CAST/EiJ ENSTCUG00005019331
 protein coding gene Chr9:50940687-50976954 (-)
CBA/J ENSMUSG00210031611
 protein coding gene Chr9:51130453-51158133 (-)
DBA/2J ENSMUSG00185036664
 protein coding gene Chr9:51156873-51184446 (-)
FVB/NJ ENSMUSG00205040940
 protein coding gene Chr9:51434543-51462118 (-)
JF1/MsJ ENSUMUG00000045692
 protein coding gene Chr9:51171711-51199379 (-)
LP/J ENSMUSG00230036967
 protein coding gene Chr9:51405256-51432964 (-)
NOD/ShiLtJ ENSMUSG00190032921
 protein coding gene Chr9:51214151-51241863 (-)
NZO/HlLtJ ENSMUSG00225027338
 protein coding gene Chr9:51420118-51447689 (-)
PWK/PhJ ENSLUMG00010032713
 protein coding gene Chr9:51130844-51158448 (-)
SPRET/EiJ ENSMSPG00010024843
 protein coding gene Chr9:52102394-52130116 (-)
WSB/EiJ ENSIUOG00005034783
 protein coding gene Chr9:50630408-50658099 (-)



Homology
more
  • Human Ortholog
    CYP19A1, cytochrome P450 family 19 subfamily A member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP19A1, cytochrome P450 family 19 subfamily A member 1
  • Synonyms
    ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM
  • Links
    NCBI Gene ID: 1588
    UniProt: P11511

  • Chr Location
    15q21.2; chr15:51208057-51338601 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Cyp19a1 mouse models; 12 with human CYP19A1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    173 phenotypes from 7 alleles in 10 genetic backgrounds
    22 phenotypes from multigenic genotypes
    3 images
    149 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for various mutations that inactivate the gene exhibit defects affecting fertility including impairments of ovulation, spermiogenesis and mounting behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    893
  • Tissues
    192
  • cDNA Data
    14
  • Literature Summary
    35
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032274 Ensembl Gene Model | MGI Sequence Detail 102174 C57BL/6J ±  kb
    transcript ENSMUST00000034811 Ensembl | MGI Sequence Detail 2373 Not Applicable  
    polypeptide ENSMUSP00000034811 Ensembl | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 6
      cDNA 15
      Primer pair 12
      Other 2
      Antibodies 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11424, MGD-MRK-11430, MGD-MRK-2301
    References
    more
    • Summaries
      All 274
      Developmental Gene Expression 35
      Diseases 4
      Gene Ontology 18
      Phenotypes 149
    • Earliest
      J:34987 Naftolin F, et al., The formation of estrogens by central neuroendocrine tissues. Recent Prog Horm Res. 1975;31:295-319
    • Latest
      J:388887 Owen CM, et al., Conditional replacement of the mouse luteinizing hormone receptor with green fluorescent protein, enabling imaging of cell migration during ovulation. Endocrinology. 2026 May 26;167(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory