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Cd69 Gene Detail
Summary
  • Symbol
    Cd69
  • Name
    CD69 antigen
  • Synonyms
    5830438K24Rik, AIM, VEA
  • Feature Type
    protein coding gene
  • IDs
    MGI:88343
    NCBI Gene: 12515
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:129244287-129252332 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.21 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88343
 protein coding gene Chr6:129244287-129252399 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031342
 protein coding gene Chr6:132928738-132936845 (-)
A/J MGP_AJ_G0031313
 protein coding gene Chr6:127841281-127849394 (-)
AKR/J MGP_AKRJ_G0031241
 protein coding gene Chr6:131335648-131343761 (-)
BALB/cJ MGP_BALBcJ_G0031320
 protein coding gene Chr6:127490016-127498141 (-)
C3H/HeJ MGP_C3HHeJ_G0031044
 protein coding gene Chr6:131521775-131529888 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031779
 protein coding gene Chr6:136419164-136427275 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028925
 protein coding gene Chr6:125346817-125354969 (-)
CAST/EiJ MGP_CASTEiJ_G0030422
 protein coding gene Chr6:131750019-131758499 (-)
CBA/J MGP_CBAJ_G0031004
 protein coding gene Chr6:141776925-141785038 (-)
DBA/2J MGP_DBA2J_G0031161
 protein coding gene Chr6:126793525-126801638 (-)
FVB/NJ MGP_FVBNJ_G0031111
 protein coding gene Chr6:125674145-125682259 (-)
LP/J MGP_LPJ_G0031241
 protein coding gene Chr6:133139673-133147849 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031149
 protein coding gene Chr6:145634149-145642259 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031812
 protein coding gene Chr6:131392670-131400915 (-)
PWK/PhJ MGP_PWKPhJ_G0030140
 protein coding gene Chr6:125075778-125083894 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029969
 protein coding gene Chr6:129417551-129427754 (-)
WSB/EiJ MGP_WSBEiJ_G0030510
 protein coding gene Chr6:131815268-131823469 (-)



Homology
more
  • Human Ortholog
    CD69, CD69 molecule
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD69, CD69 molecule
  • Synonyms
    AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3
  • Links
    NCBI Gene ID: 969
    neXtProt AC: NX_Q07108
    UniProt: Q07108

  • Chr Location
    12p13.31; chr12:9752486-9760901 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in slightly increased pre-B and immature B cell numbers in the bone marrow, and increased IgG2a and IgM response to T cell-dependent and T cell-independent antigens. Mutant mice were less prone to collagen inducedarthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    20
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12515 NCBI Gene Model | MGI Sequence Detail 8046 C57BL/6J ±  kb
    transcript NM_001033122 RefSeq | MGI Sequence Detail 1631 ZRU/MplStud  
    polypeptide P37217 UniProt | EBI | MGI Sequence Detail 199 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 9
      cDNA 22
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1869, MGI:1889838, MGI:1923299
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 1
      Gene Ontology 24
      Phenotypes 35
    • Earliest
      J:9232 Yokoyama WM, et al., Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation. J Immunol. 1988 Jul 15;141(2):369-76
    • Latest
      J:345669 Nakai S, et al., CD69 Is Indispensable for Development of Functional Local Immune Memory in Murine Contact Hypersensitivity. J Invest Dermatol. 2023 Dec 21;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory