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Rtn4r Gene Detail
Summary
  • Symbol
    Rtn4r
  • Name
    reticulon 4 receptor
  • Synonyms
    NgR, NgR1, Nogo-66 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136886
    NCBI Gene: 65079
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17945506-17970272 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.23 cM, cytoband B1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136886
 protein coding gene Chr16:17945506-17970272 (+)
129S1/SvImJ ENSMUSG00200046465
 protein coding gene Chr16:14942086-14967037 (+)
A/J ENSMUSG00195033583
 protein coding gene Chr16:14499398-14524358 (+)
AKR/J ENSMUSG00220040651
 protein coding gene Chr16:14815669-14840622 (+)
BALB/cJ ENSMUSG00180029878
 protein coding gene Chr16:14740664-14765621 (+)
C3H/HeJ ENSMUSG00175039868
 protein coding gene Chr16:14885648-14910597 (+)
C57BL/6NJ ENSMUSG00215038511
 protein coding gene Chr16:14606759-14631705 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020537
 protein coding gene Chr16:14623200-14648154 (+)
CAST/EiJ ENSTCUG00005045115
 protein coding gene Chr16:14812403-14837482 (+)
CBA/J ENSMUSG00210040266
 protein coding gene Chr16:14901953-14926902 (+)
DBA/2J ENSMUSG00185028671
 protein coding gene Chr16:14846578-14871524 (+)
FVB/NJ ENSMUSG00205044960
 protein coding gene Chr16:14856087-14881039 (+)
JF1/MsJ ENSUMUG00000051941
 protein coding gene Chr16:14940376-14965454 (+)
LP/J ENSMUSG00230037854
 protein coding gene Chr16:17425988-17450945 (+)
NOD/ShiLtJ ENSMUSG00190034609
 protein coding gene Chr16:14988009-15012954 (+)
NZO/HlLtJ ENSMUSG00225037683
 protein coding gene Chr16:20671818-20696771 (+)
PWK/PhJ ENSLUMG00010043636
 protein coding gene Chr16:14821266-14846389 (+)
SPRET/EiJ ENSMSPG00010040459
 protein coding gene Chr16:14832382-14857694 (+)
WSB/EiJ ENSIUOG00005039830
 protein coding gene Chr16:14982307-15007294 (+)



Homology
more
  • Human Ortholog
    RTN4R, reticulon 4 receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTN4R, reticulon 4 receptor
  • Synonyms
    NGR, NgR1, NOGOR
  • Links
    NCBI Gene ID: 65078
    UniProt: Q9BZR6

  • Chr Location
    22q11.21; chr22:20241415-20283246 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RTN4R associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 7 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    217 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display decreased exploration in new environment, impaired coordination, and improved recovery and rubrospinal axon regeneration following spinal cord injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    121
  • cDNA Data
    9
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 65079 NCBI Gene Model | MGI Sequence Detail 24767 C57BL/6J ±  kb
    transcript NM_022982 RefSeq | MGI Sequence Detail 1938 C57BL/6  
    polypeptide Q99PI8 UniProt | EBI | MGI Sequence Detail 473 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 9
      Primer pair 3
      Antibodies 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 289
      Developmental Gene Expression 19
      Diseases 8
      Gene Ontology 17
      Phenotypes 217
    • Earliest
      J:57757 Lindsay EA, et al., Congenital heart disease in mice deficient for the DiGeorge syndrome region [see comments]. Nature. 1999 Sep 23;401(6751):379-83
    • Latest
      J:390319 Son GY, et al., Dysregulated calcium signaling underlies hyposalivation and microbial dysbiosis in Down syndrome. Cell Rep. 2026 Jul 1;:117619
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory