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Tcf7l2 Gene Detail
Summary
  • Symbol
    Tcf7l2
  • Name
    transcription factor 7 like 2, T cell specific, HMG box
  • Synonyms
    mTcf-4B, mTcf-4E, Tcf-4, Tcf4, TCF4B, TCF4E
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202879
    NCBI Gene: 21416
  • Alliance
  • Transcription Start Sites
    79 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:55730252-55922086 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 19, 51.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4613 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202879
protein coding gene Chr19:55730227-55922091 (+)
129S1/SvImJ ENSMUSG00200014761
protein coding gene Chr19:52431236-52623580 (+)
A/J ENSMUSG00195002284
protein coding gene Chr19:52606511-52798891 (+)
AKR/J ENSMUSG00220017460
protein coding gene Chr19:52357735-52550096 (+)
BALB/cJ ENSMUSG00180017499
protein coding gene Chr19:52845647-53037991 (+)
C3H/HeJ ENSMUSG00175021364
protein coding gene Chr19:52381493-52573801 (+)
C57BL/6NJ ENSMUSG00215014137
protein coding gene Chr19:52466193-52658040 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023086
protein coding gene Chr19:52212978-52409236 (+)
CAST/EiJ ENSTCUG00005014578
protein coding gene Chr19:52015447-52208931 (+)
CBA/J ENSMUSG00210020214
protein coding gene Chr19:52460849-52653165 (+)
DBA/2J ENSMUSG00185027313
protein coding gene Chr19:52959592-53151913 (+)
FVB/NJ ENSMUSG00205003181
protein coding gene Chr19:51841531-52033792 (+)
JF1/MsJ ENSUMUG00000017326
protein coding gene Chr19:53142995-53336061 (+)
LP/J ENSMUSG00230025065
protein coding gene Chr19:53712753-53905078 (+)
NOD/ShiLtJ ENSMUSG00190011277
protein coding gene Chr19:52333775-52526015 (+)
NZO/HlLtJ ENSMUSG00225024853
protein coding gene Chr19:57318481-57510764 (+)
PWK/PhJ ENSLUMG00010017735
protein coding gene Chr19:52201079-52393316 (+)
SPRET/EiJ ENSMSPG00010003141
protein coding gene Chr19:52063359-52252361 (+)
WSB/EiJ ENSIUOG00005022466
protein coding gene Chr19:51819524-52011454 (+)



Homology
more
  • Human Ortholog
    TCF7L2, transcription factor 7 like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCF7L2, transcription factor 7 like 2
  • Synonyms
    TCF-4, TCF4
  • Links
    NCBI Gene ID: 6934
    UniProt: Q9NQB0

  • Chr Location
    10q25.2-q25.3; chr10:112950205-113167678 (+)  GRCh38

Human Diseases
more
  • Diseases
    7 with human TCF7L2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    91 phenotypes from 17 alleles in 12 genetic backgrounds
    15 phenotypes from multigenic genotypes
    79 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for a targeted mutation exhibit intestinal epithelia abnormalities and die shortly after birth. Mice heterozygous for some mutations display abnormalities in glucose homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024985 Ensembl Gene Model | MGI Sequence Detail 191835 C57BL/6J ±  kb
    transcript ENSMUST00000111657 Ensembl | MGI Sequence Detail 2135 Not Applicable  
    polypeptide ENSMUSP00000107284 Ensembl | MGI Sequence Detail 598 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 119
      cDNA 87
      Primer pair 19
      Other 13
      Antibodies 12

      Microarray probesets 8
    References
    more
    • Summaries
      All 330
      Developmental Gene Expression 169
      Gene Ontology 38
      Phenotypes 79
    • Earliest
      J:38018 Pscherer A, et al., The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene. EMBO J. 1996 Dec 2;15(23):6680-90
    • Latest
      J:377778 Kiral FR, et al., Generation of human pineal gland organoids with melatonin production for disease modeling. Cell Stem Cell. 2026 Jan 8;33(1):91-107.e9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/08/2026
    MGI 6.24
    The Jackson Laboratory