About   Help   FAQ
Ddx6 Gene Detail
Summary
  • Symbol
    Ddx6
  • Name
    DEAD-box helicase 6
  • Synonyms
    1110001P04Rik, C430015D01Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 6, E230023J21Rik, HLR2, mRCK/P54, p54, rck
  • Feature Type
    protein coding gene
  • IDs
    MGI:104976
    NCBI Gene: 13209
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44516189-44552028 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband B
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    235 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104976
 protein coding gene Chr9:44514113-44552028 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034714
 protein coding gene Chr9:43113748-43154555 (+)
A/J MGP_AJ_G0034695
 protein coding gene Chr9:41901568-41937510 (+)
AKR/J MGP_AKRJ_G0034622
 protein coding gene Chr9:42781771-42816513 (+)
BALB/cJ MGP_BALBcJ_G0034686
 protein coding gene Chr9:41649236-41685368 (+)
C3H/HeJ MGP_C3HHeJ_G0034397
 protein coding gene Chr9:43225312-43264014 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035207
 protein coding gene Chr9:44386024-44419678 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032122
 protein coding gene Chr9:41478159-41511922 (+)
CAST/EiJ MGP_CASTEiJ_G0033719
 protein coding gene Chr9:43080691-43122102 (+)
CBA/J MGP_CBAJ_G0034369
 protein coding gene Chr9:46008609-46047228 (+)
DBA/2J MGP_DBA2J_G0034528
 protein coding gene Chr9:41805562-41840752 (+)
FVB/NJ MGP_FVBNJ_G0034469
 protein coding gene Chr9:41068202-41106794 (+)
LP/J MGP_LPJ_G0034609
 protein coding gene Chr9:43412809-43446916 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034513
 protein coding gene Chr9:47844174-47887477 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035228
 protein coding gene Chr9:42688949-42725081 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0033259
 protein coding gene Chr9:42999118-43033150 (+)
WSB/EiJ MGP_WSBEiJ_G0033832
 protein coding gene Chr9:42715729-42751118 (+)



Homology
more
  • Human Ortholog
    DDX6, DEAD-box helicase 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX6, DEAD-box helicase 6
  • Synonyms
    HLR2, IDDILF, P54, RCK, Rck/p54
  • Links
    NCBI Gene ID: 1656
    neXtProt AC: NX_P26196
    UniProt: P26196

  • Chr Location
    11q23.3; chr11:118747763-118791744 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice exhibit lethality prior to E11.5, decreased embryo size, embryonic growth retardation, caudal body truncation, and delayed primitive streak formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    14
  • cDNA Data
    122
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032097 Ensembl Gene Model | MGI Sequence Detail 35840 C57BL/6J ±  kb
    transcript ENSMUST00000217034 Ensembl | MGI Sequence Detail 6029 Not Applicable  
    polypeptide ENSMUSP00000149620 Ensembl | MGI Sequence Detail 483 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 141
      Genomic 10
      cDNA 124
      Primer pair 5
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-31049, MGI:1923546, MGI:1925955, MGI:2444175
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 20
      Gene Ontology 12
      Phenotypes 15
    • Earliest
      J:30308 Seto M, et al., Cloning and expression of a murine cDNA homologous to the human RCK/P54, a lymphoma-linked chromosomal translocation junction gene on 11q23. Gene. 1995 Dec 12;166(2):293-6
    • Latest
      J:345099 Wang X, et al., Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development. BMC Genomics. 2024 Feb 3;25(1):139
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory