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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cbfb
core binding factor beta
MGI:99851
31 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\CbfbTgTn(sb-cHS4,Tyr)2512E-2Ove/\CbfbTgTn(sb-cHS4,Tyr)2512E-2Ove
FVB/N-CbfbTgTn(sb-cHS4,Tyr)2512E-2Ove 		embryonic lethality during organogenesis, complete penetrance J:175597
\Cbfbtm1Itan/\Cbfbtm1Itan
\Rr94tm3.1Litt/\Rr94tm3.1Litt
\Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N 		abnormal double-positive T cell morphology J:158962
abnormal T cell subpopulation ratio J:158962
decreased CD4-positive, alpha-beta T cell number J:158962
decreased double-positive T cell number J:158962
increased CD8-positive, alpha-beta T cell number J:158962
increased double-positive T cell number J:158962
\Cbfbtm1Itan/\Cbfbtm1Itan
\Zbtb7btm2Litt/\Zbtb7b+
\Tg(Lck-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal T cell differentiation J:141144
decreased CD4-positive, alpha-beta T cell number J:141144
\Cbfbtm1Itan/\Cbfbtm1Itan
\Zbtb7btm2Litt/\Zbtb7btm1.2Litt
\Tg(Lck-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal T cell differentiation J:141144
decreased CD4-positive, alpha-beta T cell number J:141144
\Cbfbtm2.1Ddg/\Cbfbtm2.1Ddg
\Mapttm2Arbr/?
\H2az2Tg(Wnt1-cre)11Rth/\H2az2+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J 		abnormal axon morphology J:226826
abnormal craniofacial development J:226826
abnormal nociceptor morphology J:226826
abnormal sensory neuron innervation pattern J:226826
perinatal lethality J:226826
\Cbfbtm2.1Ddg/\Cbfbtm2.1Ddg
\Mapttm2Arbr/?
\Runx1tm1(cre/Esr1*)Ims/?
involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj 		abnormal mechanoreceptor morphology J:226826
\Cbfbtm3Ppl/\Cbfb+
involves: 129S6/SvEvTac * C57BL/6 		decreased hematopoietic stem cell number J:160522
normal hematopoietic system phenotype J:160522
internal hemorrhage J:160522
lethality throughout fetal growth and development, complete penetrance J:160522
pale liver J:160522
postnatal lethality, complete penetrance J:160522
prenatal lethality, incomplete penetrance J:160522
\Cbfbtm4Ppl/\Cbfb+
involves: 129S6/SvEvTac * C57BL/6 		abnormal bone marrow cell morphology/development J:160522
absent megakaryocytes J:160522
pale liver J:160522
\Cbfbtm5Ppl/\Cbfb+
Not Specified 		abnormal mononuclear cell differentiation J:193140
myeloid hyperplasia J:193140
normal neoplasm J:193140
\Cbfbtm5Ppl/\Cbfbtm5Ppl
Not Specified 		embryonic lethality during organogenesis, complete penetrance J:193140
impaired hematopoiesis J:193140
intracranial hemorrhage J:193140
\Cbfbtm6Ppl/\Cbfb+
involves: 129S/SvEv * C57BL/6 		decreased B cell number J:252447
normal hematopoietic system phenotype J:252447
increased myeloid cell number J:252447
normal neoplasm J:252447
\Cbfbtm6Ppl/\Cbfbtm6Ppl
involves: 129S/SvEv * C57BL/6 		embryonic lethality, complete penetrance J:252447
impaired hematopoiesis J:252447
internal hemorrhage J:252447
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory