Ucp1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ucp1
uncoupling protein 1 (mitochondrial, proton carrier)
MGI:98894

27 phenotypes from 4 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ucp1^em1Yqiu/Ucp1^em1Yqiu Not Specified	decreased physiological sensitivity to xenobiotic	J:299971
Ucp1^m1H/Ucp1^m1H C57BL/6J-Ucp1^m1H/H	abnormal body temperature homeostasis	J:148827
Ucp1^{tm1b(EUCOMM)Hmgu}/Ucp1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Ucp1^{tm1b(EUCOMM)Hmgu}/Ieg	abnormal lens morphology	J:211773
	abnormal QT variability	J:211773
	abnormal sinus arrhythmia	J:211773
	cataract	J:211773
	decreased circulating triglyceride level	J:211773
	increased erythrocyte cell number	J:211773
	increased hematocrit	J:211773
	thick ventricular wall	J:211773
Ucp1^tm1Kz/Ucp1^tm1Kz 129S1.Cg-Ucp^tm1Kz	abnormal mitochondrial physiology	J:69573
	impaired adaptive thermogenesis	J:69573
	increased brown adipose tissue amount	J:69573
Ucp1^tm1Kz/Ucp1^tm1Kz (129S1.Cg-Ucp^tm1Kz x B6.Cg-Ucp^tm1Kz)F1	abnormal mitochondrial physiology	J:69573
	normal homeostasis/metabolism phenotype	J:69573
Ucp1^tm1Kz/Ucp1^tm1Kz B6.Cg-Ucp^tm1Kz	abnormal lipid homeostasis	J:81820
	abnormal mitochondrial physiology	J:69573
	decreased body weight	J:81820
	decreased circulating free fatty acids level	J:81820
	decreased circulating thyroxine level	J:81820
	decreased circulating triglyceride level	J:81820
	decreased respiratory quotient	J:81820
	decreased susceptibility to diet-induced obesity	J:81820
	decreased white adipose tissue amount	J:81820
	impaired adaptive thermogenesis	J:69573
	increased body temperature	J:81820
	increased brown adipose tissue amount	J:81820
	increased circulating triiodothyronine level	J:81820
Ucp1^tm1Kz/Ucp1^tm1Kz involves: 129S2/SvPas	abnormal oxygen consumption	J:40053
	abnormal physiological response to xenobiotic	J:40053
	decreased oxygen consumption	J:62312
	decreased susceptibility to diet-induced obesity	J:40053
	impaired adaptive thermogenesis	J:40053
	increased brown adipose tissue amount	J:40053
Ucp1^tm1Kz/Ucp1^tm1Kz involves: 129S2/SvPas * C57BL/6	impaired febrile response	J:345254
Ucp1^tm1Kz/Ucp1^tm1Kz involves: 129S2/SvPas * C57BL/6J	abnormal mitochondrial physiology	J:57998

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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