91 phenotypes from 12 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ttnem1Kage/Ttnem1Kage B6J.B6N-Ttnem1Kage	abnormal heart morphology	J:302920
	abnormal myocardium layer morphology	J:302920
	normal cardiovascular system phenotype	J:302920
	decreased ventricle muscle contractility	J:302920
	dilated heart left ventricle	J:302920
	normal muscle phenotype	J:302920
Ttnmdm/Ttnmdm involves: C57BL/6J	decreased body weight	J:87870
	normal muscle phenotype	J:87870
	premature death	J:87870
Ttnmdm/Ttnmdm Not Specified	kyphosis	J:14016
	muscle degeneration	J:14016
	myositis	J:14016
	premature death	J:14016
Ttnshru/Ttnshru B6.BTBR-Ttnshru	abnormal angiogenesis	J:92178
	abnormal blood circulation	J:92178
	abnormal blood vessel morphology	J:92178
	abnormal cardiovascular development	J:92178
	abnormal cardiovascular system morphology	J:74786
	abnormal dorsal aorta morphology	J:92178
	abnormal first pharyngeal arch morphology	J:92178
	abnormal frontonasal mesenchyme morphology	J:92178
	abnormal heart development	J:92178
	abnormal somite development	J:92178
	abnormal vitelline vascular remodeling	J:92178
	absent organized vascular network	J:92178
	cellular necrosis	J:92178
	decreased cardiac muscle contractility	J:92178
	decreased embryo size	J:92178
	embryonic lethality during organogenesis, complete penetrance	J:92178
	hemorrhage	J:92178
	hypoxia	J:92178
	increased apoptosis	J:74786
	microcephaly	J:92178
	pericardial edema	J:92178
	trabecula carnea hypoplasia	J:92178
Ttntm1.1Her/Ttntm1.1Her involves: 129S4/SvJae * 129T2/SvEms	abnormal heart ventricle morphology	J:111284
	abnormal myocardial fiber morphology	J:111284
	abnormal myocardial trabeculae morphology	J:111284
	abnormal myocardium layer morphology	J:111284
	decreased embryo size	J:111284
	embryonic growth retardation	J:111284
	increased embryonic tissue cell apoptosis	J:111284
	pericardial effusion	J:111284
	prenatal lethality, complete penetrance	J:111284
	thin myocardium	J:111284
Ttntm1.1Hgra/Ttntm1.1Hgra B6.Cg-Ttntm1.1Hgra	abnormal heart left atrium morphology	J:206712
	abnormal heart left ventricle morphology	J:206712
	abnormal myocardial fiber morphology	J:206712
	cardiac hypertrophy	J:206712
	impaired exercise endurance	J:206712
	increased heart left atrium weight	J:206712
Ttntm1.1Hgra/Ttntm1.1Hgra involves: 129S6/SvEvTac * C57BL/6J	abnormal diaphragm morphology	J:206713
	abnormal muscle contractility	J:206713
	decreased soleus weight	J:206713
	kyphosis	J:206713
	skeletal muscle fiber atrophy	J:206713
Ttntm1.1Isrd/Ttn+ involves: 129S2/SvPas * C57BL/6	abnormal limb muscle morphology	J:165576
	abnormal quadriceps morphology	J:165576
	abnormal tibialis anterior morphology	J:165576
	dystrophic muscle	J:165576
	embryonic lethality during organogenesis, incomplete penetrance	J:165576
	prenatal lethality, incomplete penetrance	J:165576
Ttntm1.1Isrd/Ttntm1.1Isrd involves: 129S2/SvPas * C57BL/6	abnormal gastrocnemius morphology	J:165576
	abnormal limb muscle morphology	J:165576
	abnormal M line morphology	J:165576
	abnormal skeletal muscle morphology	J:165576
	abnormal soleus morphology	J:165576
	abnormal tibialis anterior morphology	J:165576
	cardiac interstitial fibrosis	J:165576
	centrally nucleated skeletal muscle fibers	J:165576
	decreased ventricle muscle contractility	J:165576
	dilated cardiomyopathy	J:165576
	dilated heart left ventricle	J:165576
	dystrophic muscle	J:165576
	embryonic lethality during organogenesis, incomplete penetrance	J:165576
	impaired skeletal muscle contractility	J:165576
	increased left ventricle diastolic pressure	J:165576
	increased left ventricle systolic pressure	J:165576
	increased variability of skeletal muscle fiber size	J:165576
	myositis	J:165576
	prenatal lethality, incomplete penetrance	J:165576
	skeletal muscle fiber necrosis	J:165576
Ttntm1Brge/Ttn+ B6.Cg-Ttntm1Brge	abnormal heart left ventricle morphology	J:152736
	abnormal response/metabolism to endogenous compounds	J:152736
	cardiac interstitial fibrosis	J:152736
	normal cardiovascular system phenotype	J:152736
	decreased cardiac muscle contractility	J:152736
	dilated cardiomyopathy	J:152736
	dilated heart left ventricle	J:152736
Ttntm1Brge/Ttntm1Brge B6.Cg-Ttntm1Brge	abnormal heart development	J:152736
	abnormal myocardium layer morphology	J:152736
	absent heartbeat	J:152736
	decreased embryo size	J:152736
	embryonic growth retardation	J:152736
	embryonic lethality, complete penetrance	J:152736
	pericardial edema	J:152736
Ttntm1Her/Ttn+ Not Specified	no abnormal phenotype detected	J:81993
Ttntm1Her/Ttntm1Her Not Specified	no abnormal phenotype detected	J:81993
Ttntm1Her/Ttntm1Her Tg(Ckmm-cre)5Khn/0 Not Specified	abnormal gait	J:81993
	abnormal M line morphology	J:81993
	abnormal posture	J:81993
	abnormal sarcomere morphology	J:81993
	blepharoptosis	J:81993
	normal cardiovascular system phenotype	J:81993
	decreased body size	J:81993
	postnatal growth retardation	J:81993
	premature death	J:81993
	progressive muscle weakness	J:81993
Ttntm1Her/Ttntm1Her Tg(Myh6-cre)2182Mds/0 Not Specified	lethality throughout fetal growth and development, complete penetrance	J:81993
Ttntm1Mgot/Ttntm1Mgot involves: 129 * C57BL/6	abnormal myocardial fiber physiology	J:125922
	abnormal sarcomere morphology	J:125922
	decreased diastolic filling velocity	J:125922
	decreased heart weight	J:125922
	ventricular hypoplasia	J:125922
Ttntm2.1Hgra/Ttntm2.1Hgra B6J.Cg-Ttntm2.1Hgra	abnormal heart left ventricle morphology	J:216466
	abnormal myocardial fiber morphology	J:216466
	abnormal sarcomere morphology	J:216466
	heart left ventricle hypertrophy	J:216466
	impaired exercise endurance	J:216466
	increased heart left atrium weight	J:216466
	increased myocardial fiber size	J:216466
	thick ventricular wall	J:216466
Ttntm2.1Mgot/Ttn+ involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal muscle physiology	J:169969
Ttntm2.1Mgot/Ttntm2.1Mgot involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal cardiac muscle contractility	J:169969
	abnormal muscle physiology	J:169969
	abnormal sarcomere morphology	J:169969
	cardiac hypertrophy	J:169969
	heart left ventricle hypertrophy	J:169969
	increased heart left ventricle size	J:169969
	increased heart left ventricle weight	J:169969
	increased myocardial fiber size	J:169969
Ttntm3.1Mgot/Ttntm3.1Mgot involves: 129S6/SvEvTac * 129S7/SvEvBrd	no abnormal phenotype detected	J:172357