109 phenotypes from 9 alleles in 16 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Spta1em1(IMPC)Bay/Spta1+ C57BL/6N-Spta1em1(IMPC)Bay/BayMmucd	increased startle reflex	J:211773
Spta1em1(IMPC)Bay/Spta1em1(IMPC)Bay C57BL/6N-Spta1em1(IMPC)Bay/BayMmucd	preweaning lethality, complete penetrance	J:211773
Spta1ihj/Spta1+ involves: HRS/J * LAH	abnormal fertility/fecundity	J:105409
Spta1ihj/Spta1ihj involves: HRS/J * LAH	abnormal feces composition	J:105409
	abnormal maternal nurturing	J:105409
	abnormal spleen morphology	J:105409
	anisocytosis	J:105409
	decreased body size	J:105409
	delayed hair appearance	J:105409
	enlarged liver	J:105409
	enlarged spleen	J:105409
	hemolytic anemia	J:105409
	increased circulating bilirubin level	J:105409
	jaundice	J:105409
	microcytosis	J:105409
	pallor	J:105409
	poikilocytosis	J:105409
	polychromatophilia	J:105409
	postnatal lethality	J:105409
	reduced female fertility	J:105409
	reticulocytosis	J:105409
	spherocytosis	J:105409
Spta1sph-2Bc/Spta1sph-2Bc (WB.Cg-Spta1sph-2Bc/Brk x B6.Cg-Spta1sph-2Bc/Brk)F1	abnormal cardiac thrombosis	J:62355
	abnormal erythrocyte morphology	J:62355
	abnormal red blood cell deformability	J:81125
	microcytosis	J:62355
Spta1sph-2Bc/Spta1sph-2Bc involves: SELH	abnormal erythrocyte morphology	J:7048, J:7501
	abnormal spleen morphology	J:7048
	anisocytosis	J:7048
	decreased hematocrit	J:7048
	decreased hemoglobin content	J:7048
	enlarged spleen	J:7048
	erythroblastosis	J:7048
	extramedullary hematopoiesis	J:7048
	hemolytic anemia	J:7048
	increased bone marrow cell number	J:7048
	increased circulating bilirubin level	J:7048
	increased erythrocyte osmotic fragility	J:7048
	increased leukocyte cell number	J:7048
	jaundice	J:7048
	pallor	J:7048
	poikilocytosis	J:7048
	postnatal lethality, incomplete penetrance	J:7048
	premature death	J:7048
	reticulocytosis	J:7048
	schistocytosis	J:7048
	spherocytosis	J:7048
Spta1sph-2J/Spta1sph-2J C3HeB/FeJ-Spta1sph-2J	abnormal reticulocyte morphology	J:7501
Spta1sph-3J/Spta1sph-3J NOD.Cg-H2b Spta1sph-3J	abnormal erythrocyte morphology	J:157766
	anemia	J:157766
	anisocytosis	J:157766
	anisopoikilocytosis	J:157766
	decreased erythrocyte cell number	J:157766
	decreased hematocrit	J:157766
	decreased hemoglobin content	J:157766
	decreased mean corpuscular hemoglobin concentration	J:157766
	decreased spleen iron level	J:157766
	elliptocytosis	J:157766
	enlarged spleen	J:157766
	extramedullary hematopoiesis	J:157766
	hemolytic anemia	J:157766
	increased circulating bilirubin level	J:157766
	increased circulating iron level	J:157766
	increased kidney iron level	J:157766
	increased liver iron level	J:157766
	increased spleen weight	J:157766
	poikilocytosis	J:157766
	polychromatophilia	J:157766
	reticulocytosis	J:157766
	spherocytosis	J:157766
Spta1sph-4J/Spta1sph-4J C57BL/6J-Spta1sph-4J/Llp	abnormal erythrocyte morphology	J:157766
	anemia	J:157766
	anisocytosis	J:157766
	anisopoikilocytosis	J:157766
	decreased erythrocyte cell number	J:157766
	decreased hematocrit	J:157766
	decreased hemoglobin content	J:157766
	decreased mean corpuscular hemoglobin concentration	J:157766
	enlarged spleen	J:157766
	extramedullary hematopoiesis	J:157766
	hemolytic anemia	J:157766
	increased circulating bilirubin level	J:157766
	increased circulating iron level	J:157766
	increased kidney iron level	J:157766
	increased liver iron level	J:157766
	increased mean corpuscular volume	J:157766
	increased spleen weight	J:157766
	poikilocytosis	J:157766
	polychromatophilia	J:157766
	reticulocytosis	J:157766
	spherocytosis	J:157766
Spta1sph-Dem/Spta1sph-Dem CcS3/Dem-Spta1sph-Dem	abnormal cardiac thrombosis	J:62355
	abnormal erythrocyte morphology	J:62355
	anemia	J:66966
	elliptocytosis	J:62355, J:66966
	enlarged spleen	J:66966
	jaundice	J:66966
	liver degeneration	J:66966
	microcytosis	J:62355
	renal necrosis	J:66966
Spta1sph-ha/Spta1+ either: (B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1	increased erythrocyte protoporphyrin level	J:5985
Spta1sph-ha/Spta1+ involves: DBA/1J	increased erythrocyte clearance	J:24829
Spta1sph-ha/Spta1sph-ha (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1	abnormal cardiac thrombosis	J:62355
	abnormal erythrocyte morphology	J:62355
	abnormal erythrocyte physiology	J:162532
	abnormal red blood cell deformability	J:81125
	anisopoikilocytosis	J:162532
	cardiac hypertrophy	J:162532
	decreased body size	J:162532
	decreased hematocrit	J:162532
	decreased hemoglobin content	J:162532
	enlarged liver	J:162532
	enlarged spleen	J:162532
	extramedullary hematopoiesis	J:162532
	hemolysis	J:162532
	hemolytic anemia	J:162532
	increased circulating bilirubin level	J:162532
	increased erythrocyte clearance	J:162532
	increased erythrocyte osmotic fragility	J:162532
	increased mean corpuscular volume	J:162532
	increased nucleated erythrocyte cell number	J:162532
	infertility	J:162532
	jaundice	J:162532
	low mean erythrocyte cell number	J:162532
	microcytosis	J:62355
	poikilocytosis	J:162532
	preweaning lethality, incomplete penetrance	J:162532
	reticulocytosis	J:162532
	schistocytosis	J:162532
Spta1sph-ha/Spta1sph-ha either: (B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1	abnormal bone marrow cell number	J:1967, J:6695
	abnormal erythrocyte physiology	J:30033
	abnormal erythropoiesis	J:6695
	abnormal lung morphology	J:12830
	abnormal lymph node cell ratio	J:1967
	abnormal pulmonary alveolus wall morphology	J:12830
	abnormal spleen morphology	J:6695
	abnormal splenic cell ratio	J:1967
	abnormal thrombosis	J:12830
	alveolitis	J:12830
	blood vessel congestion	J:12830
	decreased hematocrit	J:6695
	enlarged spleen	J:6695
	extramedullary hematopoiesis	J:12830
	gallstones	J:12830
	hemolytic anemia	J:1967, J:6695, J:12830
	hemosiderosis	J:12830
	increased B cell number	J:1967
	increased B cell proliferation	J:1967
	increased bone marrow cell number	J:6695, J:12830
	increased CD4-positive, alpha-beta T cell number	J:1967
	increased CD8-positive, alpha-beta T cell number	J:1967
	increased circulating bilirubin level	J:12830
	increased erythrocyte protoporphyrin level	J:5985, J:6695
	increased erythroid progenitor cell number	J:6695
	increased IgA level	J:12830
	increased IgG level	J:12830
	increased leukocyte cell number	J:12830
	increased lymphocyte cell number	J:1967, J:12830
	increased monocyte cell number	J:12830
	increased neutrophil cell number	J:12830
	increased susceptibility to bacterial infection	J:12830
	increased T cell number	J:1967
	increased T cell proliferation	J:1967
	interstitial pneumonia	J:12830
	lymph node hyperplasia	J:1967, J:12830
	macrocytosis	J:6695
	microcytosis	J:6695
	premature death	J:12830
	pulmonary fibrosis	J:12830
	reticulocytosis	J:6695
	spherocytosis	J:6695
Spta1sph-ha/Spta1sph-ha involves: DBA/1J	abnormal bone marrow morphology	J:30699
	abnormal erythrocyte morphology	J:30699
	abnormal reticulocyte morphology	J:7501
	abnormal skin pigmentation	J:14946
	cardiac hypertrophy	J:14946
	decreased hematocrit	J:24829
	decreased hemoglobin content	J:24829
	decreased mean corpuscular volume	J:24829
	enlarged liver	J:30699
	enlarged spleen	J:14946, J:30699
	erythroblastosis	J:14946
	hemolytic anemia	J:30699
	hypochromic microcytic anemia	J:14946
	infertility	J:24729
	jaundice	J:14946, J:24729, J:30699
	microcytic anemia	J:24729
	microcytosis	J:24729
	postnatal lethality, incomplete penetrance	J:24729, J:24829
	prenatal lethality, incomplete penetrance	J:24829
Spta1sph/Spta1+ either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1	increased erythrocyte protoporphyrin level	J:5985
Spta1sph/Spta1sph (WB.C3-Spta1sph x B6.C3-Spta1sph)F1	abnormal cardiac thrombosis	J:44313, J:62355
	abnormal erythrocyte morphology	J:62355
	abnormal erythrocyte osmotic lysis	J:162532
	abnormal erythrocyte physiology	J:162532
	anisopoikilocytosis	J:162532
	brain lesion	J:44313
	cardiac hypertrophy	J:162532
	cerebral infarct	J:44313
	decreased body size	J:162532
	decreased cellular hemoglobin content	J:44313
	decreased erythrocyte cell number	J:44313
	decreased hematocrit	J:44313, J:162532
	decreased hemoglobin content	J:44313, J:162532
	enlarged heart	J:44313
	enlarged liver	J:162532
	enlarged spleen	J:44313, J:162532
	extramedullary hematopoiesis	J:162532
	focal hepatic necrosis	J:44313
	glomerulonephritis	J:44313
	hemolysis	J:162532
	hemolytic anemia	J:162532
	increased circulating bilirubin level	J:162532
	increased erythrocyte clearance	J:162532
	increased kidney iron level	J:44313
	increased liver iron level	J:44313
	increased mean corpuscular volume	J:162532
	increased nucleated erythrocyte cell number	J:162532
	infertility	J:162532
	jaundice	J:162532
	low mean erythrocyte cell number	J:162532
	microcytosis	J:62355
	myocardium necrosis	J:44313
	poikilocytosis	J:162532
	postnatal lethality, incomplete penetrance	J:44313, J:162532
	premature death	J:44313
	renal tubular necrosis	J:44313
	reticulocytosis	J:162532
	schistocytosis	J:162532
	tubular nephritis	J:44313
Spta1sph/Spta1sph B6.C3-Spta1sph/BrkJ	neonatal lethality, incomplete penetrance	J:162758
	postnatal lethality, incomplete penetrance	J:162758
Spta1sph/Spta1sph either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1	abnormal bone marrow cell number	J:6695
	abnormal erythrocyte physiology	J:30033
	abnormal erythropoiesis	J:6695
	abnormal spleen morphology	J:6695
	decreased hematocrit	J:6695
	decreased susceptibility to parasitic infection	J:111131
	enlarged spleen	J:6695
	hemolytic anemia	J:6695
	increased bone marrow cell number	J:6695
	increased erythrocyte protoporphyrin level	J:5985, J:111131
	increased erythroid progenitor cell number	J:6695
	macrocytosis	J:6695
	microcytosis	J:6695
	reticulocytosis	J:6695
	spherocytosis	J:6695
Spta1sph/Spta1sph involves: C3H	abnormal liver morphology	J:12276
	abnormal reticulocyte morphology	J:7501
	decreased hematocrit	J:12276
	decreased hemoglobin content	J:12276
	dilated liver sinusoidal space	J:12276
	enlarged liver	J:12276
	hemolytic anemia	J:12276
	increased circulating bilirubin level	J:12276
	jaundice	J:12276
	liver vascular congestion	J:12276
	neonatal lethality, complete penetrance	J:12276
	pallor	J:12276
	poikilocytosis	J:12276
	spherocytosis	J:12276
Spta1sph/Spta1sph WB.C3-Spta1sph/BrkJ	neonatal lethality, incomplete penetrance	J:162758
	postnatal lethality, complete penetrance	J:162758