About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sox4
SRY (sex determining region Y)-box 4
MGI:98366
57 phenotypes from 7 alleles in 10 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
\Sox4em1(IMPC)Mbp/\Sox4+
C57BL/6NCrl-Sox4em1(IMPC)Mbp/MbpMmucd 		abnormal bone structure J:211773
abnormal brain morphology J:211773
abnormal gallbladder morphology J:211773
abnormal retina blood vessel morphology J:211773
abnormal retina morphology J:211773
abnormal retina vasculature morphology J:211773
abnormal uterus morphology J:211773
decreased body length J:211773
decreased brain size J:211773
enlarged gallbladder J:211773
enlarged uterus J:211773
increased circulating alkaline phosphatase level J:211773
increased freezing behavior J:211773
persistence of hyaloid vascular system J:211773
\Sox4em1(IMPC)Mbp/\Sox4em1(IMPC)Mbp
C57BL/6NCrl-Sox4em1(IMPC)Mbp/MbpMmucd 		abnormal heart morphology J:211773
abnormal hindbrain development J:211773
abnormal neural tube closure J:211773
abnormal neural tube morphology J:211773
preweaning lethality, complete penetrance J:211773
\Sox4Igt4/\Sox4+
involves: C3H/HeH * C57BL/6 		decreased circulating insulin level J:141688
decreased insulin secretion J:141688
impaired glucose tolerance J:141688
\Sox4Igt4/\Sox4Igt4
involves: C3H/HeH * C57BL/6 		lethality throughout fetal growth and development, complete penetrance J:141688
\Sox4Igt4/\Sox4M91Ark
involves: C3H/HeH * C57BL/6 		lethality throughout fetal growth and development, complete penetrance J:141688
\Sox4M91Ark/\Sox4+
involves: C3H/HeH 		decreased circulating insulin level J:141688
decreased insulin secretion J:141688
impaired glucose tolerance J:141688
\Sox4tm1.1Vlf/\Sox4+
involves: 129 * C57BL/6 * FVB/N 		thick interventricular septum J:175338
\Sox4tm1.1Vlf/\Sox4tm1.1Vlf
involves: 129 * C57BL/6 * SJL 		abnormal interventricular septum morphology J:130461
abnormal semilunar valve development J:130461
edema J:130461
persistent truncus arteriosus J:130461
prenatal lethality, complete penetrance J:130461
\Sox4tm1Cle/\Sox4tm1Cle
involves: 129P2/OlaHsd * C57BL/6 		abnormal aorticopulmonary septum morphology J:32741
abnormal B cell differentiation J:32741
abnormal blood circulation J:32741
abnormal conotruncal ridge morphology J:51464
abnormal coronary artery morphology J:51464
abnormal semilunar valve morphology J:32741
absent pre-B cells J:32741
decreased pro-B cell number J:32741
failure of conotruncal ridge closure J:32741
hydrops fetalis J:32741
increased heart rate J:32741
lethality throughout fetal growth and development, complete penetrance J:32741
perimembraneous ventricular septal defect J:32741
persistent right dorsal aorta J:51464
tracheoesophageal fistula J:51464
\Sox4tm1Vlf/\Sox4tm1Vlf
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		no abnormal phenotype detected J:130461
\Sox4tm1Vlf/\Sox4tm1Vlf
\Tg(CAG-cre/Esr1*)5Amc/0
involves: 129 * C57BL/6 * CBA * SJL 		abnormal interventricular septum morphology J:130461
abnormal semilunar valve development J:130461
edema J:130461
persistent truncus arteriosus J:130461
prenatal lethality, complete penetrance J:130461
\Sox4tm1Vlf/\Sox4tm1Vlf
\Tg(Dbh-icre)1Gsc/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal nervous system development J:157923
abnormal sympathetic ganglion morphology J:157923
\Sox4tm1Vlf/\Sox4tm1Vlf
\Tg(Six3-cre)69Frty/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2 		abnormal axon fasciculation J:199663
abnormal eye development J:199663
abnormal retina bipolar cell morphology J:199663
abnormal retina morphology J:199663
decreased amacrine cell number J:199663
decreased retina ganglion cell number J:199663
increased retina apoptosis J:199663
optic nerve hypoplasia J:199663
thin retina ganglion layer J:199663
thin retina inner nuclear layer J:199663
normal vision/eye phenotype J:199663
\Sox4tm2Cle/\Sox4tm2Cle
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell differentiation J:32741
abnormal blood circulation J:32741
abnormal semilunar valve morphology J:32741
absent pre-B cells J:32741
decreased pro-B cell number J:32741
failure of conotruncal ridge closure J:32741
hydrops fetalis J:32741
increased heart rate J:32741
lethality throughout fetal growth and development, complete penetrance J:32741
ventricular septal defect J:32741
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory