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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Srsf2
serine and arginine-rich splicing factor 2
MGI:98284
29 phenotypes from 3 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Myl2tm1(cre)Krc/Myl2+
Srsf2tm1Xdfu/Srsf2tm1Xdfu
involves: 129S4/SvJae
cardiac interstitial fibrosis J:88432
normal cardiovascular system phenotype J:88432
decreased ventricle muscle contractility J:88432
dilated cardiomyopathy J:88432
pregnancy-related premature death J:88432
Srsf2tm1.1Oaw/Srsf2+
Tg(Mx1-cre)1Cgn/?
B6.Cg-Tg(Mx1-cre)1Cgn Srsf2tm1.1Oaw
abnormal cell cycle J:221404
abnormal erythroid progenitor cell morphology J:221404
abnormal erythropoiesis J:221404
abnormal hematopoietic stem cell physiology J:221404
abnormal hematopoietic system physiology J:221404
abnormal myelopoiesis J:221404
abnormal neutrophil morphology J:221404
decreased B cell number J:221404
failure of myelopoiesis J:221404
impaired hematopoiesis J:221404
increased apoptosis J:221404
increased hematopoietic stem cell number J:221404
macrocytic anemia J:221404
Srsf2tm1.1Xdfu/Srsf2tm1.1Xdfu
involves: 129S4/SvJae * FVB/N
embryonic lethality between implantation and somite formation, complete penetrance J:88432
Srsf2tm1Xdfu/Srsf2+
Tg(Lck-cre)I57Jxm/?
involves: 129S4/SvJae * 129X1/SvJ * ICR
decreased thymocyte number J:88668
decreased thymus weight J:88668
Srsf2tm1Xdfu/Srsf2tm1Xdfu
Tg(Lck-cre)I57Jxm/?
involves: 129S4/SvJae * 129X1/SvJ * ICR
abnormal spleen white pulp morphology J:88668
abnormal T cell differentiation J:88668
absent thymus corticomedullary boundary J:88668
decreased double-positive T cell number J:88668
decreased T cell number J:88668
decreased thymocyte number J:88668
increased double-negative T cell number J:88668
small thymus J:88668
Srsf2tm1Xdfu/Srsf2tm1Xdfu
Tg(Mx1-cre)1Cgn/?
involves: 129S4/SvJae * C57BL/6J * CBA/J
abnormal hematopoietic system physiology J:221404
bone marrow failure J:221404
impaired hematopoiesis J:221404

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory