Furin Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Furin
furin, paired basic amino acid cleaving enzyme
MGI:97513

47 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Furin^tm1.1Jwmc/Furin^tm1.1Jwmc involves: 129P2/OlaHsd * BALB/c * C57BL/6J	embryonic lethality during organogenesis, complete penetrance	J:118515
Furin^tm1Ajmr/Furin^tm1Ajmr involves: 129P2/OlaHsd * C57BL/6	abnormal allantois morphology	J:50582
	abnormal cardinal vein morphology	J:50582
	abnormal developmental patterning	J:50582
	abnormal dorsal-ventral axis patterning	J:50582
	abnormal extraembryonic tissue morphology	J:50582
	abnormal heart development	J:50582
	abnormal heart tube morphology	J:50582
	abnormal neural plate morphology	J:50582
	abnormal somite shape	J:50582
	abnormal ventral body wall morphology	J:50582
	abnormal visceral yolk sac blood island morphology	J:50582
	absent midgut	J:50582
	absent vitelline blood vessels	J:50582
	cardia bifida	J:50582
	decreased embryo size	J:50582
	decreased somite size	J:50582
	embryonic lethality during organogenesis, complete penetrance	J:50582
	excessive folding of visceral yolk sac	J:50582
	exencephaly	J:50582
	failure of chorioallantoic fusion	J:50582
	failure of heart looping	J:50582
	failure of initiation of embryo turning	J:50582
	kinked neural tube	J:50582
	short rostral-caudal axis	J:50582
Furin^{tm1b(EUCOMM)Wtsi}/Furin⁺ C57BL/6N-Furin^{tm1b(EUCOMM)Wtsi}/Cnrm	abnormal vibrissa morphology	J:211773
	brachydactyly	J:211773
Furin^{tm1b(EUCOMM)Wtsi}/Furin^{tm1b(EUCOMM)Wtsi} C57BL/6N-Furin^{tm1b(EUCOMM)Wtsi}/Cnrm	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Furin^tm1Jwmc/Furin^tm1.1Jwmc Tg(Mx1-cre)1Cgn/0 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/6J * CBA	normal liver/biliary system phenotype	J:118515
Furin^tm1Jwmc/Furin^tm1Jwmc involves: 129P2/OlaHsd * C57BL/6J	no abnormal phenotype detected	J:118515
Furin^tm1Jwmc/Furin^tm1Jwmc Tg(Cd4-cre)1Cwi/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal regulatory T cell physiology	J:204761
Furin^tm1Jwmc/Furin^tm1Jwmc Tg(Gdf9-icre)5092Coo/0 involves: 129P2/OlaHsd * C57BL/6J * CBA/J	decreased granulosa cell proliferation	J:272231
	female infertility	J:272231
	impaired ovarian folliculogenesis	J:272231
	increased secondary ovarian follicle number	J:272231
Furin^tm1Jwmc/Furin^tm1Jwmc Tg(Zp3-cre)3Mrt/0 involves: 129P2/OlaHsd * C57BL/6J * CBA/J	abnormal meiotic spindle morphology	J:272231
	abnormal oocyte morphology	J:272231
	abnormal primary polar body morphology	J:272231
	abnormal secondary ovarian follicle number	J:272231
	anovulation	J:272231
	decreased granulosa cell proliferation	J:272231
	decreased mature ovarian follicle number	J:272231
	decreased superovulation rate	J:272231
	decreased tertiary ovarian follicle number	J:272231
	failure of superovulation	J:272231
	female infertility	J:272231
	impaired ovarian folliculogenesis	J:272231
	increased atretic ovarian follicle number	J:272231
	increased granulosa cell apoptosis	J:272231
	small ovary	J:272231

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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