Furin^tm1Ajmr
Targeted Allele Detail

Summary

• Symbol: Furin^tm1Ajmr
• Name: furin, paired basic amino acid cleaving enzyme; targeted mutation 1, Anton JM Roebroek
• MGI ID: MGI:1857604
• Synonyms: fur -, Spc1^-
• Gene: Furin Location: Chr7:80038942-80055188 bp, - strand Genetic Position: Chr7, 45.65 cM, cytoband D1-E2
• Alliance: Furin^tm1Ajmr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50582
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of a PGK- hygromycin resistance gene with adapter sequences created an in-frame stop codon in exon 4. Northern analysis was used to confirm the lack of transcript in homozygous mutant animals (J:50582)

Expression

In Mice Carrying this Mutation:	52 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Furin Mutation: 45 strains or lines available

References

• Original: J:50582 Roebroek AJ, et al., Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin. Development. 1998 Dec;125(24):4863-76
• All: 7 reference(s)