88 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pax8tm1(cre)Mbu/Pax8tm1(cre)Mbu involves: 129P2/OlaHsd * C3H/He * C57BL/6	absent thyroid gland	J:80208
	lethality at weaning, complete penetrance	J:80208
	postnatal growth retardation	J:80208
Pax8tm1Pgr/Pax8+ either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	increased circulating thyroid-stimulating hormone level	J:47310
Pax8tm1Pgr/Pax8tm1Pgr either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	abnormal action potential	J:119449, J:119450
	abnormal adenohypophysis morphology	J:117324
	abnormal auditory bulla morphology	J:116236
	abnormal caput epididymis morphology	J:117324
	abnormal cochlear hair cell morphology	J:116236
	abnormal cochlear hair cell stereociliary bundle morphology	J:116236
	abnormal cochlear IHC efferent innervation pattern	J:119450
	abnormal cochlear inner hair cell physiology	J:119449, J:119450
	abnormal corpus epididymis morphology	J:117324
	abnormal epididymis epithelium morphology	J:117324
	abnormal external auditory canal morphology	J:116236
	abnormal inner hair cell synaptic ribbon morphology	J:119450
	abnormal kinocilium morphology	J:116236
	abnormal middle ear morphology	J:116236
	abnormal middle ear ossicle morphology	J:116236
	abnormal Mullerian duct morphology	J:129545
	abnormal organ of Corti morphology	J:119450
	abnormal outer ear morphology	J:116236
	abnormal outer hair cell stereociliary bundle morphology	J:116236
	abnormal pillar cell morphology	J:116236
	abnormal stapedial artery morphology	J:116236
	abnormal stapes crus morpholgy	J:116236
	abnormal stapes morphology	J:116236
	abnormal thyroid diverticulum morphology	J:47310
	abnormal thyroid gland development	J:47310
	abnormal thyroid gland morphology	J:47310
	abnormal uterus development	J:129545
	absent efferent ductules of testis	J:117324
	absent endometrium	J:129545
	absent epididymis	J:117324
	absent outer ear	J:116236
	absent round window	J:116236
	absent stapedial artery	J:116236
	absent thyroid follicular cells	J:47310
	absent uterine horn	J:129545
	arrest of spermatogenesis	J:117324
	cochlear outer hair cell degeneration	J:116236
	deafness	J:116236
	decreased circulating thyroxine level	J:47310, J:116236
	decreased circulating triiodothyronine level	J:116236
	decreased lactotroph cell number	J:117324
	decreased round window size	J:116236
	decreased somatotroph cell number	J:117324
	decreased testis weight	J:117324
	delayed inner ear development	J:116236
	dilated oviduct	J:129545
	dilated uterine cervix	J:129545
	enlarged tectorial membrane	J:116236
	external auditory canal stenosis	J:116236
	female infertility	J:129545
	increased or absent threshold for auditory brainstem response	J:116236
	increased thyrotroph cell number	J:117324
	lethality at weaning, complete penetrance	J:129545
	male infertility	J:117324
	postnatal growth retardation	J:47310, J:116236
	postnatal lethality, complete penetrance	J:116236
	premature death	J:47310
	small ears	J:116236
	small epididymis	J:117324
	small thyroid gland	J:47310
	testicular atrophy	J:117324
	thin myometrium	J:129545
	uterus hypoplasia	J:129545
	vagina atresia	J:129545
Pax8tm1Pgr/Pax8tm1Pgr involves: 129S1/Sv * 129X1/SvJ	abnormal bone remodeling	J:130062
	abnormal bone trabecula morphology	J:130062
	abnormal epiphyseal plate morphology	J:130062
	decreased bone mineral density of femur	J:130062
	decreased bone mineral density of humerus	J:130062
	decreased bone mineralization	J:130062
	decreased bone volume	J:130062
	decreased compact bone thickness	J:130062
	decreased femur compact bone thickness	J:130062
	delayed bone ossification	J:130062
	delayed endochondral bone ossification	J:130062
	increased thyroid-stimulating hormone level	J:130062
	short limbs	J:130062
Pax8tm1Rdl/Pax8+ B6.129-Pax8tm1Rdl	no abnormal phenotype detected	J:220108
Pax8tm1Rdl/Pax8tm1.1(cre)Mbu B6.129(Cg)-Pax8tm1Rdl Pax8tm1.1(cre)Mbu	abnormal thyroid follicle morphology	J:220108
	abnormal thyroid follicular cell morphology	J:220108
	abnormal thyroid gland morphology	J:220108
	decreased activity of thyroid gland	J:220108
	decreased body size	J:220108
	decreased body weight	J:220108
	decreased circulating thyroxine level	J:220108
	delayed ear emergence	J:220108
	delayed eyelid opening	J:220108
	increased apoptosis	J:220108
	increased circulating thyroid-stimulating hormone level	J:220108
	premature death	J:220108
	small thyroid gland	J:220108
Pax8tm1Rdl/Pax8tm1.1(cre)Mbu involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	increased apoptosis	J:178498