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Targeted Allele Detail
Symbol: Pax8tm1Pgr
Name: paired box 8; targeted mutation 1, Peter Gruss
MGI ID: MGI:2156985
Synonyms: Pax8-
Gene: Pax8  Location: Chr2:24310572-24365611 bp, - strand  Genetic Position: Chr2, 16.43 cM, cytoband B
Alliance: Pax8tm1Pgr page
Germline Transmission:  Earliest citation of germline transmission: J:47310
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe vector containing a neo cassette was targeted to exon 2. A thymidine kinase gene was inserted at the 3' end of the construct. This leads to complete inactivation as the putative splicing from exon 1 to exon 3 renders the codons out of frame, terminating after 11 heterologous amino acids. (J:47310)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 45 assay results
In Structures Affected by this Mutation: 34 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pax8 Mutation:  32 strains or lines available
Original:  J:47310 Mansouri A, et al., Follicular cells of the thyroid gland require Pax8 gene function. Nat Genet. 1998 May;19(1):87-90
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory