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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pax6
paired box 6
MGI:97490
46 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Emx2tm1Sia/\Emx2tm1Sia
\Pax6Sey/\Pax6Sey
involves: C57BL/6 * CBA 		abnormal Ammon gyrus morphology J:98539
abnormal brain commissure morphology J:98539
abnormal brain morphology J:98539
abnormal cerebral cortex morphology J:98539
abnormal embryonic/fetal subventricular zone morphology J:98539
abnormal pretectal region morphology J:98539
abnormal tectum morphology J:98539
abnormal telencephalon morphology J:98539
abnormal thalamus morphology J:98539
absent choroid plexus J:98539
absent diencephalon J:98539
absent hippocampus J:98539
\Gli2tm1Alj/\Gli2tm1Alj
\Pax6Sey/\Pax6Sey
involves: 129S1/Sv * 129X1/SvJ 		abnormal neuron differentiation J:112802
\Mitfmi-vga9/\Mitf+
\Pax6Sey-Neu/\Pax6+
involves: C57BL/6 * CBA 		abnormal retina pigment epithelium morphology J:188155
\Mitfmi-vga9/\Mitfmi-vga9
\Pax6Sey-Neu/\Pax6+
involves: C57BL/6 * CBA 		abnormal retina pigment epithelium morphology J:188155
\Mitfmi-vga9/\Mitfmi-vga9
\Pax6Sey-Neu/\Pax6Sey-Neu
involves: C57BL/6 * CBA 		abnormal retina pigment epithelium morphology J:188155
\Mitftm3.1Arnh/\Mitftm3.1Arnh
\Pax6Sey-Neu/\Pax6+
involves: 129S6/SvEvTac * C57BL/6N 		abnormal retina pigment epithelium morphology J:188155
\Pax6Sey-H/\Pax6+
involves: 101/H * C3H/HeH 		belly spot J:8534
coloboma J:8534
decreased body size J:8534
lowered ear position J:8534
microphthalmia J:8534
reduced female fertility J:8534
small ears J:8534
\Pax6Sey-H/\Pax6Sey-H
involves: 101/H * C3H/HeH 		embryonic lethality, complete penetrance J:8534
\Pax6Sey-Neu/\Pax6+
\Sox2tm1.1Vep/\Sox2+
involves: 102 * C3H * C3H/HeN 		abnormal lens morphology J:119175
\Pax6Sey/\Pax6Sey-H
involves: 101/H * C3H/HeH * C57BL/10 		abnormal face development J:8534
abnormal maxillary shelf morphology J:8534
absent snout J:8534
anophthalmia J:8534
decreased embryo size J:8534
\Pax6Sey/\Pax6Sey-Neu
\Tg(Hbb-b1)83Clo/0
involves: 102 * C3H * C57BL * CBA/Ca * CD-1 * SJL 		abnormal craniofacial bone morphology J:43913
abnormal nasal capsule morphology J:43913
supernumerary incisors J:43913
\Pax6Sey/\Pax6Sey
\Tg(Hbb-b1)83Clo/0
involves: C57BL * CBA/Ca * CD-1 * SJL 		abnormal craniofacial bone morphology J:43913
abnormal nasal capsule morphology J:43913
supernumerary incisors J:43913
\Pax6Sey/\Pax6Sey
\Tg(PAX6)77Ndha/?
involves: C57BL/6 * CBA 		normal nervous system phenotype J:34194
normal taste/olfaction phenotype J:34194
normal vision/eye phenotype J:34194
\Pax6tm2(Pax6_i5a,Pax2)Xzh/\Pax6+
involves: 129S6/SvEvTac 		normal vision/eye phenotype J:198381
\Pax6tm2(Pax6_i5a,Pax2)Xzh/\Pax6tm2(Pax6_i5a,Pax2)Xzh
involves: 129S6/SvEvTac 		abnormal eye development J:198381
abnormal neuronal precursor proliferation J:198381
abnormal retina development J:198381
abnormal telencephalon development J:198381
thin cortical plate J:198381
\Pax6tm2.1(Pax6_i5a,Pax2)Xzh/\Pax6+
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		corneal-lenticular stalk J:198381
\Pax6tm2.1(Pax6_i5a,Pax2)Xzh/\Pax6tm2.1(Pax6_i5a,Pax2)Xzh
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		abnormal cortical plate morphology J:198381
abnormal eye development J:198381
abnormal neuronal precursor proliferation J:198381
abnormal retina development J:198381
abnormal telencephalon development J:198381
\Pax6tm2Pgr/\Pax6tm2Pgr
\Smarcc2tm1.1Stoy/\Smarcc2+
\Emx1tm1(cre)Krj/\Emx1+
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 		abnormal neuron number J:197141
normal nervous system phenotype J:197141
\Pax6tm2Pgr/\Pax6tm2Pgr
\Smarcc2tm1.1Stoy/\Smarcc2tm1.1Stoy
\Emx1tm1(cre)Krj/\Emx1+
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 		abnormal neocortex morphology J:197141
abnormal neuron number J:197141
abnormal neuronal precursor cell number J:197141
\Pax6tm2Pgr/\Pax6tm2Pgr
\Sox2tm1.1Lan/\Sox2tm1.1Lan
\Tg(Cryaa-cre)10Mlr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL 		abnormal lens epithelium morphology J:152850
increased lens epithelium apoptosis J:152850
microphthalmia J:152850
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory