131 phenotypes from 28 alleles in 41 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sor+ H2az2Tg(Wnt1-cre)11Rth/H2az2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	cleft palate	J:137730
Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sor+ Pax3tm1(cre)Joe/Pax3+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased palatal length	J:137730
	normal limbs/digits/tail phenotype	J:137730
	normal muscle phenotype	J:137730
Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:137730
Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe H2az2Tg(Wnt1-cre)11Rth/H2az2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	abnormal craniofacial morphology	J:137730
	abnormal eyelid morphology	J:137730
	abnormal palate morphology	J:137730
Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe Pax3tm1(cre)Joe/Pax3+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal bone mineralization	J:137730
	abnormal bone ossification	J:137730
	abnormal craniofacial bone morphology	J:137730
	abnormal eyelid development	J:137730
	abnormal forelimb morphology	J:137730
	abnormal osteoblast differentiation	J:137730
	abnormal pterygoid process morphology	J:137730
	abnormal secondary palate development	J:137730
	absent alisphenoid bone	J:137730
	absent eyelids	J:137730
	absent pterygoid process	J:137730
	alisphenoid bone hypoplasia	J:137730
	cleft palate	J:137730
	decreased tympanic ring size	J:137730
	failure of eyelid fusion	J:137730
	failure of palatal shelf elevation	J:137730
	hypaxial muscle hypoplasia	J:137730
	normal limbs/digits/tail phenotype	J:137730
	normal muscle phenotype	J:137730
	normal nervous system phenotype	J:137730
	postnatal lethality	J:137730
Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe Pax3tm1(cre)Joe/Pax3tm1(cre)Joe involves: 129S1/Sv * 129X1/SvJ * C57BL/6	postnatal lethality	J:137730
Pax3M1Btlr/Pax3M1Btlr C57BL/6J-Pax3M1Btlr	variable body spotting	J:221484
Pax3m2Btlr/Pax3m2Btlr C57BL/6J-Pax3M2Btlr	variable body spotting	J:234261
Pax3Rwa/Pax3+ B6N.Cg-Pax3Rwa	abnormal hind foot hair pigmentation	J:241031
	abnormal tail hair pigmentation	J:241031
	abnormal ventral coat pigmentation	J:241031
	belly spot	J:241031
	curly tail	J:241031
	spina bifida	J:241031
	transverse fur striping	J:241031
Pax3Rwa/Pax3Rwa B6N.Cg-Pax3Rwa	abnormal embryo morphology	J:241031
	decreased embryo size	J:241031
	embryonic lethality	J:241031
	open neural tube	J:241031
Pax3Sp-1H/Pax3Sp-1H involves: 101/H * C3H * C3H/HeH	abnormal lateral ventricle morphology	J:19818
	exencephaly	J:19818
	incomplete rostral neuropore closure	J:19818
Pax3Sp-1H/Pax3Sp-1H involves: 101/H * C3H/HeH * C57BL/6	abnormal common carotid artery morphology	J:88412
	abnormal dorsal root ganglion morphology	J:88412
	abnormal pharyngeal arch artery morphology	J:88412
	abnormal sixth pharyngeal arch artery morphology	J:88412
	abnormal spinal cord morphology	J:88412
	abnormal thymus morphology	J:88412
	abnormal thyroid gland morphology	J:88412
	absent thyroid gland	J:88412
	absent ultimobranchial body	J:88412
	common truncal valve	J:88412
	double outlet right ventricle	J:88412
	lethality throughout fetal growth and development, complete penetrance	J:88412
	open neural tube	J:88412
	persistent right dorsal aorta	J:88412
	persistent truncus arteriosus	J:88412
	retroesophageal right subclavian artery	J:88412
	small thyroid gland	J:88412
Pax3Sp-1Wli/Pax3+ involves: C57BL/6J * CBA/CaJ	belly spot	J:196572
	white spotting	J:196572
Pax3Sp-1Wli/Pax3Sp-1Wli involves: C57BL/6J * CBA/CaJ	abnormal neural tube morphology	J:196572
	embryonic lethality during organogenesis, incomplete penetrance	J:196572
	exencephaly	J:196572
	prenatal lethality, complete penetrance	J:196572
	spina bifida	J:196572
Pax3Sp-1Xzg/Pax3+ C57BL/6J-Pax3Sp-1Xzg	belly spot	J:196566
	curly tail	J:196566
	decreased tail pigmentation	J:196566
	hypopigmentation	J:196566
	white spotting	J:196566
Pax3Sp-1Xzg/Pax3Sp-1Xzg C57BL/6J-Pax3Sp-1Xzg	abnormal limb morphology	J:196566
	embryonic lethality during organogenesis, complete penetrance	J:196566
	exencephaly	J:196566
	open neural tube	J:196566
	spina bifida	J:196566
Pax3Sp-2H/Pax3+ involves: 101 * C3H/He * CBA/Ca	belly spot	J:46341
Pax3Sp-2H/Pax3+ involves: C57BL/6	belly spot	J:14096
	diluted coat color	J:14096
Pax3Sp-2H/Pax3Sp-2H involves: 101 * C3H/He	abnormal myocardial fiber physiology	J:46341
	abnormal neural fold elevation formation	J:46341
	decreased ventricle muscle contractility	J:46341
	dilated heart left ventricle	J:46341
	dilated heart right ventricle	J:46341
	exencephaly	J:46341
	lethality throughout fetal growth and development, incomplete penetrance	J:46341
	open neural tube	J:46341
	persistent truncus arteriosus	J:46341
	ventricular septal defect	J:46341
Pax3Sp-2H/Pax3Sp-2H involves: 101 * C3H/He * CBA/Ca	abnormal myocardial fiber physiology	J:46341
	abnormal neural fold elevation formation	J:46341
	abnormal neural tube morphology	J:60939
	decreased ventricle muscle contractility	J:46341
	dilated heart left ventricle	J:46341
	dilated heart right ventricle	J:46341
	exencephaly	J:46341, J:60939
	lethality throughout fetal growth and development, incomplete penetrance	J:46341
	open neural tube	J:46341, J:60939
	persistent truncus arteriosus	J:46341
	spina bifida	J:60939
	ventricular septal defect	J:46341
Pax3Sp-2H/Pax3Sp-2H involves: C57BL/6	abnormal dermomyotome development	J:32016
	abnormal muscle precursor cell migration	J:32016
	abnormal myogenesis	J:18227, J:32016
	prenatal lethality, complete penetrance	J:14096
	spina bifida	J:14096
Pax3Sp-2H/Pax3Sp-2H involves: DBA/2	exencephaly	J:60939
	open neural tube	J:60939
	spina bifida	J:60939
Pax3Sp-2H/Pax3Sp-2H involves: NZW	exencephaly	J:60939
	open neural tube	J:60939
	spina bifida	J:60939
Pax3Sp-2J/Pax3+ C3H/HeJ-Pax3Sp-2J	belly spot	J:238
	head spot	J:238
Pax3Sp-2J/Pax3+ involves: C3H/HeJ * C57BL/6J	belly spot	J:238
Pax3Sp-2J/Pax3Sp-2J either: C3H/HeJ-Pax3Sp-2J or (involves: C3H/HeJ * C57BL/6J)	prenatal lethality, complete penetrance	J:238
Pax3Sp-3J/Pax3+ involves: C57BL/6J	belly spot	J:238
Pax3Sp-5H/Pax3Sp-5H involves: 101/H * C3H/HeH	decreased body size	J:27501
	embryonic lethality, incomplete penetrance	J:27502
	normal nervous system phenotype	J:27502
	white spotting	J:27501
Pax3Sp-6H/Pax3Sp-6H involves: 101/H * C3H/HeH	decreased body size	J:27501
	white spotting	J:27501
Pax3Sp-7H/Pax3+ involves: C3H/HeH * C57BL/6	abnormal coat/hair pigmentation	J:93195
	belly spot	J:93195
Pax3Sp-7H/Pax3Sp-7H involves: C3H/HeH * C57BL/6	abnormal hindbrain morphology	J:93195
	abnormal neural crest cell migration	J:93195
	delayed neural tube closure	J:93195
Pax3Sp-10J/Pax3+ C57BL/6J-Pax3Sp-10J/GrsrJ	belly spot	J:162227
	curly tail	J:162227
	normal vision/eye phenotype	J:162227
	white spotting	J:162227
Pax3Sp-10J/Pax3Sp-10J C57BL/6J-Pax3Sp-10J/GrsrJ	prenatal lethality, complete penetrance	J:162227
Pax3Sp-d/Pax3+ C57BL/6J-Pax3Sp-d	belly spot	J:238
Pax3Sp-d/Pax3Sp-d C57BL/6J-Pax3Sp-d	abnormal dorsal root ganglion morphology	J:70476
	abnormal neural tube morphology	J:70476
	caudal rachischisis	J:238
	curly tail	J:70476
	disorganized dorsal root ganglion	J:70476
	exencephaly	J:70476
	perinatal lethality, complete penetrance	J:238
	spina bifida	J:70476
Pax3Sp-J/Pax3+ C57BL/6J-Pax3Sp-J	belly spot	J:238
Pax3Sp/Pax3+ C57BL-Pax3Sp	belly spot	J:12957
	white spotting	J:12957
Pax3Sp/Pax3+ involves: C3HeB * C57BL * C57BL/6J * SWV	spina bifida	J:114747
Pax3Sp/Pax3+ involves: C57BL * C57BL/6J * CBA	normal hearing/vestibular/ear phenotype	J:2179
Pax3Sp/Pax3Sp BR.B-Pax3Sp	perinatal lethality, complete penetrance	J:11996
	spina bifida cystica	J:11996
Pax3Sp/Pax3Sp C57BL-Pax3Sp	abnormal brain ventricle morphology	J:13016
	abnormal dorsal root ganglion morphology	J:13016
	abnormal midbrain development	J:5443, J:13016
	abnormal neural tube morphology	J:6190, J:13016
	abnormal tail morphology	J:13016
	absent coat pigmentation	J:13016
	absent skin pigmentation	J:13016
	increased mitotic index	J:13016
	kinked tail	J:12957
	lethality throughout fetal growth and development, complete penetrance	J:12957
	open neural tube	J:5443, J:13016
	small embryonic telencephalon	J:13016
	spina bifida	J:12957
Pax3Sp/Pax3Sp involves: 129S2/SvPas * C57BL * C57BL/6J * FVB	increased embryonic neuroepithelium apoptosis	J:75569
	open neural tube	J:75569
Pax3Sp/Pax3Sp involves: C57BL	abnormal bony labyrinth	J:114748
	abnormal dermomyotome development	J:32016, J:112275
	abnormal endolymphatic duct morphology	J:114748
	abnormal hypoglossal cord morphology	J:112275
	abnormal muscle precursor cell migration	J:32016
	abnormal myogenesis	J:18227, J:32016, J:112275
	abnormal otic vesicle development	J:114748
	abnormal semicircular canal morphology	J:114748
	abnormal utricle morphology	J:114748
	abnormal vestibular saccule morphology	J:114748
	decreased cochlea coiling	J:114748
	embryonic lethality during organogenesis, complete penetrance	J:11996
	open neural tube	J:114748
	short endolymphatic duct	J:114748
	spina bifida	J:110617, J:112275
Pax3tm1(cre)Joe/Pax3tm1(cre)Joe Not Specified	abnormal diaphragm development	J:137730
	abnormal hindlimb morphology	J:137730
	abnormal neural tube morphology	J:137730
	exencephaly	J:137730
	open neural tube	J:137730
	postnatal lethality, complete penetrance	J:137730
	thin diaphragm muscle	J:137730
Pax3tm1(cre)Joe/Pax3tm2Joe involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:159124
Pax3tm1.1Sjc/Pax3+ involves: 129X1/SvJ * C3H * C57BL/6	no abnormal phenotype detected	J:75127
Pax3tm1.1Sjc/Pax3tm1.2Sjc involves: 129X1/SvJ * C3H * C57BL/6	belly spot	J:75127
	head spot	J:75127
Pax3tm1.2Sjc/Pax3tm1.2Sjc involves: 129X1/SvJ * C3H * C57BL/6	embryonic lethality during organogenesis, complete penetrance	J:75127
Pax3tm1Buck/Pax3+ involves: 129P2/OlaHsd	belly spot	J:86911
Pax3tm1Buck/Pax3Sp involves: 129P2/OlaHsd * C57BL	abnormal dermomyotome development	J:86911
	abnormal myogenesis	J:86911
	abnormal neural crest cell migration	J:86911
	absent dorsal root ganglion	J:86911
	exencephaly	J:86911
	open neural tube	J:86911
	prenatal lethality, complete penetrance	J:86911
Pax3tm1Buck/Pax3tm1Buck involves: 129P2/OlaHsd	abnormal dermomyotome development	J:176192
	abnormal dorsal root ganglion morphology	J:176192
	abnormal muscle development	J:176192
	abnormal muscle precursor cell migration	J:176192
	abnormal myogenesis	J:86911
	abnormal myotome development	J:176192
	abnormal neural crest cell migration	J:176192
	abnormal neural tube morphology	J:86911
	abnormal somite development	J:86911, J:176192
	exencephaly	J:176192
	prenatal lethality, complete penetrance	J:86911
	spina bifida	J:176192
Pax3tm1Buck/Pax3tm1Buck involves: 129P2/OlaHsd * C57BL/6	abnormal mammary line morphology	J:109476
	abnormal mammary placode morphology	J:109476
	abnormal somite development	J:109476
Pax3tm2(PAX3/FOXO1A)Buck/Pax3+ involves: 129S2/SvPas	belly spot	J:86911
Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+ involves: 129S2/SvPas * BALB/c * C57BL/6	abnormal dermomyotome development	J:86911
	abnormal intercostal muscle morphology	J:86911
	abnormal muscle development	J:86911
	abnormal myogenesis	J:86911
	abnormal myotome morphology	J:86911
	abnormal skeletal muscle morphology	J:86911
	abnormal somite border morphology	J:86911
	abnormal somite development	J:86911
	perinatal lethality, complete penetrance	J:86911
	rib fusion	J:86911
Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3Sp involves: 129S2/SvPas * BALB/c * C57BL * C57BL/6	abnormal muscle development	J:86911
	abnormal rib development	J:86911
	abnormal somite border morphology	J:86911
	prenatal lethality, complete penetrance	J:86911
Pax3tm2.1Joe/Pax3tm2.1Joe either: (involves: 129S1/Sv * 129X1/SvJ * BALB/cJ) or (involves: 129S1/Sv * 129X1/SvJ * FVB/N)	no abnormal phenotype detected	J:159124
Pax3tm2Joe/Pax3+ involves: 129S1/Sv * 129X1/SvJ	belly spot	J:159124
Pax3tm2Joe/Pax3tm2Joe involves: 129S1/Sv * 129X1/SvJ	abnormal cardiac outflow tract development	J:159124
	absent hypaxial muscle	J:159124
	exencephaly	J:159124
	persistent truncus arteriosus	J:159124
	prenatal lethality, complete penetrance	J:159124
	spina bifida	J:159124
Pax3tm2Joe/Pax3tm2Joe H2az2Tg(Wnt1-cre)11Rth/H2az2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J	normal cardiovascular system phenotype	J:159124
	cyanosis	J:159124
	decreased birth body size	J:159124
	hypaxial muscle hypoplasia	J:159124
	neonatal lethality, complete penetrance	J:159124
	respiratory failure	J:159124
	spina bifida	J:159124
Pax3tm3(Pax7)Buck/Pax3+ involves: 129S2/SvPas	variable depigmentation	J:90568
Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck involves: 129S2/SvPas	abnormal muscle development	J:90568
	abnormal neural crest cell migration	J:90568
	absent dorsal root ganglion	J:90568
	spina bifida	J:90568
Pax3tm5.1Buck/Pax3+ involves: 129S2/SvPas * BALB/c * C57BL/6	abnormal dermomyotome development	J:112275
	abnormal myogenesis	J:112275
	perinatal lethality, complete penetrance	J:112275
	spina bifida	J:112275
Pax3tm6.2Buck/Pax3tm6.2Buck involves: 129S2/SvPas * C57BL/6 * SJL	exencephaly	J:176192