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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nf2
neurofibromin 2
MGI:97307
38 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Cdkn2atm1.1Brn/\Cdkn2a+
\Nf2tm2Gth/\Nf2tm2Gth
\Trp53tm1Brn/\Trp53tm1Brn
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		increased mesothelioma incidence J:132943
increased metastatic potential J:132943
increased rhabdomyosarcoma incidence J:132943
increased tumor incidence J:132943
pleural effusion J:132943
\Cdkn2atm1.1Brn/\Cdkn2atm1.1Brn
\Nf2tm2Gth/\Nf2tm2Gth
involves: 129P2/OlaHsd * FVB/N 		abnormal meninges morphology J:131179
hydrocephaly J:131179
increased liver tumor incidence J:131179
increased meningioma incidence J:131179
increased osteoma incidence J:131179
osseous metaplasia J:131179
\Cdkn2atm1.1Brn/\Cdkn2atm1.1Brn
\Nf2tm2Gth/\Nf2tm2Gth
\Ptgdstm1.1(cre)Gvn/\Ptgds+
involves: 129P2/OlaHsd * FVB/N 		increased meningioma incidence J:173718
normal mortality/aging J:173718
normal neoplasm J:173718
\Cdkn2atm1.1Brn/\Cdkn2atm1.1Brn
\Nf2tm2Gth/\Nf2tm2Gth
\Trp53tm1Brn/\Trp53tm1Brn
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		increased mesothelioma incidence J:132943
increased rhabdomyosarcoma incidence J:132943
increased Schwannoma incidence J:132943
increased tumor incidence J:132943
premature death J:132943
\Cdkn2atm2Brn/\Cdkn2a+
\Nf2tm2Gth/\Nf2tm2Gth
involves: 129P2/OlaHsd 		enlarged liver J:132943
increased leukemia incidence J:132943
increased tumor incidence J:132943
increased uterus leiomyoma incidence J:132943
premature death J:132943
\Cdkn2atm2Brn/\Cdkn2atm2Brn
\Nf2tm2Gth/\Nf2+
involves: 129P2/OlaHsd 		increased leukemia incidence J:132943
increased tumor incidence J:132943
increased uterus leiomyoma incidence J:132943
premature death J:132943
\Cdkn2atm2Brn/\Cdkn2atm2Brn
\Nf2tm2Gth/\Nf2tm2Gth
involves: 129P2/OlaHsd 		enlarged liver J:132943
increased leukemia incidence J:132943
increased rhabdomyosarcoma incidence J:132943
increased tumor incidence J:132943
increased uterus leiomyoma incidence J:132943
premature death J:132943
\Hrastm1Jaf/\Hrastm1Jaf
\Nf2tm2Gth/\Nf2tm2Gth
\Tg(TPO-cre)1Shk/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/NCr 		increased thyroid tumor incidence J:231492
\Nf2tm2Gth/\Nf2+
\Trp53tm1Brd/\Trp53+
\Tg(Mpz-cre)3Brn/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N 		increased neurofibrosarcoma incidence J:92413
increased osteoma incidence J:92413
increased osteosarcoma incidence J:92413
increased skeletal tumor incidence J:92413
premature death J:92413
\Nf2tm2Gth/\Nf2+
\Trp53tm1Brn/\Trp53tm1Brn
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		increased leukemia incidence J:132943
increased mesothelioma incidence J:132943
increased Schwannoma incidence J:132943
increased tumor incidence J:132943
increased uterus leiomyoma incidence J:132943
premature death J:132943
\Nf2tm2Gth/\Nf2tm2Gth
\Ptgdstm1.1(cre)Gvn/\Ptgds+
\Trp53tm1Brn/\Trp53tm1Brn
involves: 129P2/OlaHsd * FVB/N 		increased nervous system tumor incidence J:173718
increased osteosarcoma incidence J:173718
premature death J:173718
\Nf2tm2Gth/\Nf2tm2Gth
\Trp53tm1Brd/\Trp53+
\Tg(Mpz-cre)2Brn/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N 		abnormal osteoblast morphology J:92413
abnormal renal tubule morphology J:92413
abnormal Schwann cell morphology J:92413
abnormal tooth development J:92413
cataract J:92413
decreased survivor rate J:92413
increased leiomyosarcoma incidence J:92413
increased nervous system tumor incidence J:92413
increased neurofibroma incidence J:92413
increased neurofibrosarcoma incidence J:92413
increased sarcoma incidence J:92413
increased Schwannoma incidence J:92413
osseous metaplasia J:92413
premature death J:92413
\Nf2tm2Gth/\Nf2tm2Gth
\Trp53tm1Brd/\Trp53+
\Tg(Mpz-cre)3Brn/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N 		decreased survivor rate J:92413
increased neurofibrosarcoma incidence J:92413
premature death J:92413
\Nf2tm2Gth/\Nf2tm2Gth
\Trp53tm1Brd/\Trp53tm1Brd
\Tg(Mpz-cre)2Brn/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N 		abnormal osteoblast morphology J:92413
abnormal renal tubule morphology J:92413
abnormal Schwann cell morphology J:92413
cataract J:92413
increased extremity angiosarcoma incidence J:92413
increased neurofibrosarcoma incidence J:92413
increased osteoma incidence J:92413
increased osteosarcoma incidence J:92413
increased rhabdomyosarcoma incidence J:92413
increased sarcoma incidence J:92413
increased tumor incidence J:92413
osseous metaplasia J:92413
premature death J:92413
\Nf2tm2Gth/\Nf2tm2Gth
\Trp53tm1Brn/\Trp53+
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		enlarged liver J:132943
increased leukemia incidence J:132943
increased mesothelioma incidence J:132943
increased Schwannoma incidence J:132943
increased tumor incidence J:132943
increased uterus leiomyoma incidence J:132943
premature death J:132943
\Nf2tm2Gth/\Nf2tm2Gth
\Trp53tm1Brn/\Trp53tm1Brn
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		enlarged liver J:132943
increased leukemia incidence J:132943
increased mesothelioma incidence J:132943
increased rhabdomyosarcoma incidence J:132943
increased Schwannoma incidence J:132943
increased T cell derived lymphoma incidence J:132943
increased tumor incidence J:132943
increased uterus leiomyoma incidence J:132943
premature death J:132943
\Nf2tm2Gth/\Nf2tm2Gth
\Yap1tm1.1Dupa/\Yap1+
\Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * DBA 		enlarged liver J:162628
normal liver/biliary system phenotype J:162628
normal neoplasm J:162628
\Nf2tm2Gth/\Nf2tm2Gth
\Yap1tm1.1Dupa/\Yap1tm1.1Dupa
\Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * DBA 		normal liver/biliary system phenotype J:162628
normal neoplasm J:162628
\Nf2tm2Gth/\Nf2tm2Gth
\Yap1tm2.1Dupa/\Yap1tm2.1Dupa
involves: 129P2/OlaHsd 		abnormal bile duct epithelium morphology J:223215
abnormal bile duct physiology J:223215
enlarged liver J:223215
increased hamartoma incidence J:223215
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory