Fabp4 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fabp4
fatty acid binding protein 4, adipocyte
MGI:88038

30 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apoe^tm1Unc/Apoe^tm1Unc Fabp4^tm1Brsp/Fabp4^tm1Brsp Fabp5^tm1Hota/Fabp5^tm1Hota B6.Cg-Fabp4^tm1Brsp Fabp5^tm1Hota Apoe^tm1Unc	decreased body weight	J:102223
	decreased circulating cholesterol level	J:102223
	decreased circulating glucose level	J:102223
	decreased circulating triglyceride level	J:102223
	decreased susceptibility to atherosclerosis	J:102223
	improved glucose tolerance	J:102223
	increased insulin sensitivity	J:102223
	normal mortality/aging	J:102223
Fabp4^tm1Brsp/Fabp4^tm1Brsp Fabp5^tm1Hota/Fabp5^tm1Hota B6.Cg-Fabp4^tm1Brsp Fabp5^tm1Hota	decreased circulating glucose level	J:111878
	increased insulin sensitivity	J:111878
Fabp4^tm1Brsp/Fabp4^tm1Brsp Fabp5^tm1Hota/Fabp5^tm1Hota involves: 129S7/SvEvBrd * C57BL/6J * SJL	abnormal brown adipose tissue morphology	J:217245
	abnormal brown adipose tissue thermogenesis	J:217245
	decreased body surface temperature	J:217245
	decreased brown adipose tissue mass	J:217245
	decreased circulating glucose level	J:217245
	decreased glycogen level	J:217245
	decreased skeletal muscle glycogen level	J:217245
	decreased triglyceride level	J:217245
	impaired adaptive thermogenesis	J:217245
	increased circulating free fatty acids level	J:217245
	normal muscle phenotype	J:217245
Fabp4^tm1Brsp/Fabp4^tm1Brsp Fabp5^tm1Hota/Fabp5^tm1Hota Lep^ob/Lep^ob B6.Cg-Fabp4^tm1Brsp Fabp5^tm1Hota Lep^ob	abnormal gluconeogenesis	J:111878
	abnormal glucose homeostasis	J:111878
	abnormal glycogen homeostasis	J:111878
	decreased circulating cholesterol level	J:111878
	decreased circulating glucose level	J:111878
	decreased circulating insulin level	J:111878
	decreased circulating triglyceride level	J:111878
	decreased liver triglyceride level	J:111878
	decreased susceptibility to hepatic steatosis	J:111878
	improved glucose tolerance	J:111878
	increased adipocyte glucose uptake	J:111878
	increased body weight	J:111878
	increased fatty acids level	J:111878
	increased insulin sensitivity	J:111878
	increased muscle cell glucose uptake	J:111878
	increased white adipose tissue amount	J:111878
	small liver	J:111878
Fabp4^tm1Brsp/Fabp4^tm1Brsp Lep^ob/Lep^ob B6.Cg-Fabp4^tm1Brsp Lep^ob	improved glucose tolerance	J:111878
	increased insulin sensitivity	J:111878

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23