Grk2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Grk2
G protein-coupled receptor kinase 2
MGI:87940

39 phenotypes from 3 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Grk2^tm1.1Gwd/Grk2^tm1.1Gwd involves: 129S4/SvJaeSor * FVB/N	abnormal heart tube morphology	J:126501
	embryonic growth arrest	J:126501
	embryonic growth retardation	J:126501
	embryonic lethality during organogenesis, complete penetrance	J:126501
	pericardial edema	J:126501
Grk2^tm1Gwd/Grk2^tm1Gwd involves: 129S4/SvJaeSor	no abnormal phenotype detected	J:126501
Grk2^tm1Gwd/Grk2^tm1Gwd Cd79a^tm1(cre)Reth/Cd79a⁺ involves: 129 * BALB/c * C57BL/6	abnormal B cell physiology	J:176118
	decreased B cell number	J:176118
	increased B cell number	J:176118
	increased CD4-positive, alpha-beta T cell number	J:176118
	increased CD8-positive, alpha-beta T cell number	J:176118
	increased follicular B cell number	J:176118
	increased marginal zone B cell number	J:176118
Grk2^tm1Gwd/Grk2^tm1Gwd Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6	normal cardiovascular system phenotype	J:126501
	decreased physiological sensitivity to xenobiotic	J:126501
	increased physiological sensitivity to xenobiotic	J:126501
	normal mortality/aging	J:126501
Grk2^tm1Gwd/Grk2^tm1Mca Tg(Cd4-cre)1Cwi/0 involves: 129 * C57BL/6 * DBA/2	abnormal T cell physiology	J:176118
	decreased CD4-positive, alpha-beta T cell number	J:176118
	decreased CD8-positive, alpha-beta T cell number	J:176118
	decreased T cell number	J:176118
	impaired leukocyte tethering or rolling	J:176118
	increased B cell number	J:176118
Grk2^tm1Mca/Grk2^tm1Mca involves: 129	abnormal interventricular septum morphology	J:36567
	abnormal myocardial trabeculae morphology	J:36567
	decreased embryo size	J:36567
	decreased ventricle muscle contractility	J:36567
	dilated heart right atrium	J:36567
	disorganized myocardium	J:36567
	embryonic lethality during organogenesis, incomplete penetrance	J:36567
	fetal growth retardation	J:36567
	heart atrium hypoplasia	J:36567
	heart hypoplasia	J:36567
	lethality throughout fetal growth and development, complete penetrance	J:36567
	pallor	J:36567
	thin myocardium	J:36567
	thin myocardium compact layer	J:36567
	thin ventricular wall	J:36567
	trabecula carnea hypoplasia	J:36567
	ventricular hypoplasia	J:36567

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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