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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prdm14
PR domain containing 14
MGI:3588194
53 phenotypes from 6 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA 		abnormal leukocyte morphology J:202090
abnormal thymus physiology J:202090
anemia J:202090
arrested B cell differentiation J:202090
decreased B cell number J:202090
decreased double-positive T cell number J:202090
decreased mature B cell number J:202090
decreased pre-B cell number J:202090
decreased pro-B cell number J:202090
distended abdomen J:202090
enlarged kidney J:202090
enlarged liver J:202090
enlarged lymph nodes J:202090
enlarged spleen J:202090
enlarged thymus J:202090
increased acute lymphoblastic leukemia incidence J:202090
increased CD8-positive, alpha-beta T cell number J:202090
increased inflammatory response J:202090
increased large unstained cell number J:202090
increased leukocyte cell number J:202090
increased single-positive T cell number J:202090
intermingled spleen red and white pulp J:202090
intestinal inflammation J:202090
kidney inflammation J:202090
lethargy J:202090
liver inflammation J:202090
meningitis J:202090
premature death J:202090
respiratory distress J:202090
stomach inflammation J:202090
thrombocytopenia J:202090
Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+
Tg(MMTV-cre)4Mam/0
involves: C57BL/6J * C57BL/6N * FVB/N 		abnormal leukocyte morphology J:202090
abnormal thymus physiology J:202090
anemia J:202090
arrested B cell differentiation J:202090
decreased B cell number J:202090
decreased double-positive T cell number J:202090
decreased mature B cell number J:202090
decreased pre-B cell number J:202090
decreased pro-B cell number J:202090
distended abdomen J:202090
enlarged kidney J:202090
enlarged liver J:202090
enlarged lymph nodes J:202090
enlarged spleen J:202090
enlarged thymus J:202090
increased acute lymphoblastic leukemia incidence J:202090
increased CD8-positive, alpha-beta T cell number J:202090
increased inflammatory response J:202090
increased large unstained cell number J:202090
increased leukocyte cell number J:202090
increased single-positive T cell number J:202090
intermingled spleen red and white pulp J:202090
intestinal inflammation J:202090
kidney inflammation J:202090
lethargy J:202090
liver inflammation J:202090
meningitis J:202090
premature death J:202090
respiratory distress J:202090
stomach inflammation J:202090
thrombocytopenia J:202090
Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+
Tg(Lck-icre)3779Nik/0
involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA/2 		normal immune system phenotype J:202090
normal neoplasm J:202090
Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo
Tg(MMTV-cre)4Mam/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB 		abnormal common lymphocyte progenitor cell morphology J:202090
increased hematopoietic stem cell number J:202090
Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal common lymphocyte progenitor cell morphology J:202090
increased hematopoietic stem cell number J:202090
Prdm14em1(IMPC)Bay/Prdm14em1(IMPC)Bay
C57BL/6N-Prdm14em1(IMPC)Bay/Bay 		abnormal bone structure J:211773
abnormal eye anterior chamber depth J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased lean body mass J:211773
increased total body fat amount J:211773
preweaning lethality, incomplete penetrance J:211773
Prdm14tm1a(EUCOMM)Wtsi/Prdm14tm1a(EUCOMM)Wtsi
C57BL/6N-Prdm14tm1a(EUCOMM)Wtsi/Bay 		abnormal bone structure J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased lean body mass J:211773
decreased respiratory quotient J:211773
hyperactivity J:211773
impaired glucose tolerance J:211773
increased effector memory T-helper cell number J:211773
increased total body fat amount J:211773
male infertility J:211773
short tibia J:211773
Prdm14tm1b(EUCOMM)Wtsi/Prdm14tm1b(EUCOMM)Wtsi
C57BL/6N-Prdm14tm1b(EUCOMM)Wtsi/Bay 		abnormal bone structure J:211773
abnormal rib morphology J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased lean body mass J:211773
female infertility J:211773
increased total body fat amount J:211773
male infertility J:211773
Prdm14tm1e(EUCOMM)Wtsi/Prdm14tm1e(EUCOMM)Wtsi
involves: C57BL/6N 		abnormal primordial germ cell morphology J:200019
Prdm14tm1Sait/Prdm14tm1Sait
B6.129P2-Prdm14tm1Sait 		absent germ cells J:138571
female infertility J:138571
male infertility J:138571
Prdm14tm1Sait/Prdm14tm1Sait
Tg(Prdm1-Venus)1Sait/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal primordial germ cell morphology J:138571
decreased primordial germ cell number J:138571
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory