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Prdm14 Gene Detail
Summary
  • Symbol
    Prdm14
  • Name
    PR domain containing 14
  • Feature Type
    protein coding gene
  • IDs
    MGI:3588194
    NCBI Gene: 383491
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:13183681-13197387 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 4.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    507 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3588194
 protein coding gene Chr1:13183649-13197467 (-)
129S1/SvImJ ENSMUSG00200018406
 protein coding gene Chr1:10508977-10522464 (-)
A/J ENSMUSG00195027413
 protein coding gene Chr1:10336253-10349740 (-)
AKR/J ENSMUSG00220008081
 protein coding gene Chr1:10406767-10420258 (-)
BALB/cJ ENSMUSG00180023412
 protein coding gene Chr1:10402579-10416065 (-)
C3H/HeJ ENSMUSG00175000225
 protein coding gene Chr1:10331369-10344854 (-)
C57BL/6NJ ENSMUSG00215009386
 protein coding gene Chr1:10378918-10392623 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013953
 protein coding gene Chr1:9076649-9088084 (-)
CAST/EiJ ENSTCUG00005021739
 protein coding gene Chr1:10786113-10799492 (-)
CBA/J ENSMUSG00210002595
 protein coding gene Chr1:10201839-10215324 (-)
DBA/2J ENSMUSG00185003725
 protein coding gene Chr1:11277744-11292722 (-)
FVB/NJ ENSMUSG00205012689
 protein coding gene Chr1:10490259-10503748 (-)
JF1/MsJ ENSUMUG00000017089
 protein coding gene Chr1:10570706-10584279 (-)
LP/J ENSMUSG00230018259
 protein coding gene Chr1:11238326-11251811 (-)
NOD/ShiLtJ ENSMUSG00190025622
 protein coding gene Chr1:10309820-10323306 (-)
NZO/HlLtJ ENSMUSG00225005193
 protein coding gene Chr1:14634810-14648500 (-)
PWK/PhJ ENSLUMG00010020956
 protein coding gene Chr1:10165720-10179457 (-)
SPRET/EiJ ENSMSPG00010026038
 protein coding gene Chr1:10855218-10868388 (-)
WSB/EiJ ENSIUOG00005011414
 protein coding gene Chr1:10338115-10353036 (-)



Homology
more
  • Human Ortholog
    PRDM14, PR/SET domain 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRDM14, PR/SET domain 14
  • Synonyms
    PFM11
  • Links
    NCBI Gene ID: 63978
    UniProt: Q9GZV8

  • Chr Location
    8q13.3; chr8:70049063-70072782 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRDM14 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 6 alleles in 11 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit decreased primordial germ cell numbers, absent germ cells, and sterility in both males and females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    124
  • cDNA Data
    5
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042414 Ensembl Gene Model | MGI Sequence Detail 13707 C57BL/6J ±  kb
    transcript ENSMUST00000047577 Ensembl | MGI Sequence Detail 2564 Not Applicable  
    polypeptide ENSMUSP00000044245 Ensembl | MGI Sequence Detail 561 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 5
      Primer pair 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 9
      Gene Ontology 15
      Phenotypes 25
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:364135 Tracey LJ, et al., Functional and molecular single-cell analyses implicate PRDM14 in the initiation of B cell leukemia in mice. Sci Rep. 2025 Mar 14;15(1):8827
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory