Coxfa4l3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Coxfa4l3
cytochrome c oxidase associated subunit FA4L3
MGI:3034182

20 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Coxfa4l3^em1Ms/Coxfa4l3^em1Ms C57BL/6J-Coxfa4l3^em1Ms	abnormal mitochondrial physiology	J:386425
	asthenozoospermia	J:386425
	decreased cellular ATP level	J:386425
	decreased cytochrome-c oxidase activity	J:386425
	decreased mitochondria enzyme/coenzyme activity	J:386425
	decreased sperm progressive motility	J:386425
	normal reproductive system phenotype	J:386425
Coxfa4l3^em1Nyam/Coxfa4l3^em1Nyam C57BL/6J-Coxfa4l3^em1Nyam	abnormal kidney morphology	J:347271
	abnormal mitochondrial physiology	J:347271
	abnormal thymus cortex morphology	J:347271
	abnormal thymus medulla morphology	J:347271
	decreased CD4-positive, alpha-beta T cell number	J:347271
	decreased glutathione level	J:347271
	impaired autophagy	J:347271
	increased cellular ATP level	J:347271
	increased cellular sensitivity to hydrogen peroxide induced cell death	J:347271
	increased IgG level	J:347271
	kidney inflammation	J:347271
	liver inflammation	J:347271
	lung inflammation	J:347271
Coxfa4l3^em1Nyam/Coxfa4l3^em1Nyam C.B6-Coxfa4l3^em1Nyam	increased susceptibility to autoimmune disorder	J:347271

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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