Coxfa4l3^em1Nyam
Endonuclease-mediated Allele Detail

Summary

• Symbol: Coxfa4l3^em1Nyam
• Name: cytochrome c oxidase associated subunit FA4L3; endonuclease-mediated mutation 1, Noritaka Yamaguchi
• MGI ID: MGI:7624377
• Synonyms: C15orf48^-
• Gene: Coxfa4l3 Location: Chr2:122479807-122482996 bp, + strand Genetic Position: Chr2, 60.64 cM
• Alliance: Coxfa4l3^em1Nyam page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using crRNA 5- ACGCUUAUAAAAAACGCCAAGUUUUAGAGCUAUGCU-3 generated a 7 bp deletion (GGCGTTT) in exon 3. Western blot analysis confirmed the absence of protein in testes extracts. (J:347271)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Coxfa4l3 Mutation: 8 strains or lines available

References

• Original: J:347271 Takakura Y, et al., Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity. Nat Commun. 2024 Feb 1;15(1):953
• All: 1 reference(s)