AA467197 MGI Mouse Gene Detail - MGI:3034182 - expressed sequence AA467197

Symbol

AA467197
Name

expressed sequence AA467197
Synonyms

NMES1

Feature Type

protein coding gene
IDs

MGI:3034182
NCBI Gene: 433470
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:122479807-122482996 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 60.64 cM
Mapping Data

1 experiment

SNPs within 2kb

48 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3034182	protein coding gene	Chr2:122478906-122483111 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026418	protein coding gene	Chr2:125678200-125682415 (+)
A/J	MGP_AJ_G0026380	protein coding gene	Chr2:120544959-120549174 (+)
AKR/J	MGP_AKRJ_G0026356	protein coding gene	Chr2:123996884-124001099 (+)
BALB/cJ	MGP_BALBcJ_G0026392	protein coding gene	Chr2:120834097-120838312 (+)
C3H/HeJ	MGP_C3HHeJ_G0026136	protein coding gene	Chr2:124473653-124477868 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026839	protein coding gene	Chr2:129790796-129795001 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024216	protein coding gene	Chr2:115470486-115474906 (+)
CAST/EiJ	MGP_CASTEiJ_G0025598	protein coding gene	Chr2:124725162-124730079 (+)
CBA/J	MGP_CBAJ_G0026116	protein coding gene	Chr2:134387757-134391972 (+)
DBA/2J	MGP_DBA2J_G0026250	protein coding gene	Chr2:119974651-119978866 (+)
FVB/NJ	MGP_FVBNJ_G0026214	protein coding gene	Chr2:118739251-118743465 (+)
LP/J	MGP_LPJ_G0026355	protein coding gene	Chr2:125919029-125923244 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026235	protein coding gene	Chr2:138581073-138585287 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026893	protein coding gene	Chr2:124038989-124043204 (+)
PWK/PhJ	MGP_PWKPhJ_G0025334	protein coding gene	Chr2:119553522-119557728 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025135	protein coding gene	Chr2:123117632-123122809 (+)
WSB/EiJ	MGP_WSBEiJ_G0025671	protein coding gene	Chr2:124910002-124914216 (+)

Human Ortholog

C15orf48, chromosome 15 open reading frame 48

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C15orf48, chromosome 15 open reading frame 48
Synonyms

COXFA4L3, FOAP-11, MIR147BHG, MISTRAV, MOCCI, NMES1
Links

HGNC:29898

NCBI Gene ID: 84419

neXtProt AC: NX_Q9C002

UniProt: Q9C002
Chr Location

15q21.1; chr15:45430579-45448761 (+) GRCh38

MGI Vertebrate Homology

AA467197 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: C15orf48
Gene Tree

AA467197

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Phenotype Summary

14 phenotypes from 1 allele in 2 genetic backgrounds
1 phenotype from multigenic genotypes
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Genomic Mutations

2 involving AA467197
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

35

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

3
CCDS

CCDS38224.1

Ensembl

ENSMUSG00000033213 (Evidence)
NCBI Gene

433470

			Length	Strain/Species	Flank
genomic	433470	NCBI Gene Model \| MGI Sequence Detail	3190	C57BL/6J	± kb
transcript	NM_001004174	RefSeq \| MGI Sequence Detail	640	C57BL/6
polypeptide	Q810Q5	UniProt \| EBI \| MGI Sequence Detail	83	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011288 normal mucosa of esophagus-specific gene 1 protein

(term hierarchy)
InterPro Domains

IPR010530 NADH-ubiquinone reductase complex 1 MLRQ subunit

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All nucleic 35

cDNA 35

Microarray probesets 1

Summaries

All 25

Gene Ontology 5

Phenotypes 5
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:347271 Takakura Y, et al., Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity. Nat Commun. 2024 Feb 1;15(1):953

TSS for AA467197:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19853	Chr2:122478882-122478893 (+)	-919 bp
Tssr19854	Chr2:122479764-122479784 (+)	-33 bp
Tssr19855	Chr2:122479787-122479843 (+)	8 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23