Coxfa4l3^em1Ms
Endonuclease-mediated Allele Detail

Summary

• Symbol: Coxfa4l3^em1Ms
• Name: cytochrome c oxidase associated subunit FA4L3; endonuclease-mediated mutation 1, National Institute of Genetics, Mishima
• MGI ID: MGI:8347484
• Synonyms: Coxfa4l3^-
• Gene: Coxfa4l3 Location: Chr2:122479807-122482996 bp, + strand Genetic Position: Chr2, 60.64 cM
• Alliance: Coxfa4l3^em1Ms page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-Cas9 targeting of exon 3 deleted 11 bp. Western blot analysis demonstrated the complete absence of COXFA4L3 protein expression in testis lysates from homozygous mutant mice, with no detectable change in COXFA4 protein expression. (J:386425)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Coxfa4l3 Mutation: 5 strains or lines available

References

• Original: J:386425 Tokito R, et al., COXFA4L3 enhances mitochondrial complex IV function to boost ATP synthesis and drive sperm motility. Mitochondrion. 2026;86(102082)
• All: 1 reference(s)