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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mcu
mitochondrial calcium uniporter
MGI:3026965
25 phenotypes from 4 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
McuGt(IST11669F8)Tigm/McuGt(IST11669F8)Tigm
involves: C57BL/6 * C57BL/6N * CD-1 		abnormal mitochondrial physiology J:208297
normal cardiovascular system phenotype J:208297
normal cellular phenotype J:208297
decreased body size J:208297
decreased body weight J:208297
decreased grip strength J:208297
normal homeostasis/metabolism phenotype J:208297
impaired exercise endurance J:208297
increased circulating lactate level J:208297
Mcutm1.1Jmol/Mcutm1.1Jmol
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N 		abnormal myocardial fiber morphology J:224853
abnormal myocardial fiber physiology J:224853
normal cardiovascular system phenotype J:224853
decreased aerobic running capacity J:224853
decreased cardiomyocyte apoptosis J:224853
decreased myocardial infarct size J:224853
decreased ventricle muscle contractility J:224853
Mcutm1.1Jmol/Mcutm1.1Jmol
Speer6-ps1Tg(Alb-cre)21Mgn/0
involves: 129S6/SvEvTac * C57BL/6 * DBA 		normal cellular phenotype J:298361
normal liver/biliary system phenotype J:298361
Mcutm1.1Jmol/Mcutm1.1Jmol
Tg(Cdh5-cre)7Mlia/0
involves: 129S6/SvEvTac * C57BL/6J * FVB/N 		abnormal mitochondrial physiology J:235756
decreased lung endothelial cell migration J:235756
decreased lung endothelial cell proliferation J:235756
Mcutm1b(EUCOMM)Hmgu/Mcu+
C57BL/6N-Mcutm1b(EUCOMM)Hmgu/H 		decreased bone mineral content J:211773
decreased lean body mass J:211773
increased circulating cholesterol level J:211773
increased circulating HDL cholesterol level J:211773
increased fasting circulating glucose level J:211773
increased total body fat amount J:211773
Mcutm1b(EUCOMM)Hmgu/Mcutm1b(EUCOMM)Hmgu
C57BL/6N-Mcutm1b(EUCOMM)Hmgu/H 		preweaning lethality, complete penetrance J:211773
Mcutm1c(EUCOMM)Hmgu/Mcutm1c(EUCOMM)Hmgu
Tg(Gabra6-cre)B1Lfr/0
involves: C57BL/6N * DBA/2 		normal cellular phenotype J:281635
Mcutm1c(EUCOMM)Hmgu/Mcutm1c(EUCOMM)Hmgu
Tg(Pcp2-cre)2Mpin/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N 		abnormal mitochondrial physiology J:281635
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory