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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Rc3h1
RING CCCH (C3H) domains 1
MGI:2685397
64 phenotypes from 6 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Rc3h1Gt(CC0753)Wtsi/Rc3h1Gt(CC0753)Wtsi
B6.129P2-Rc3h1Gt(CC0753)Wtsi
chronic liver inflammation J:199407
ileum inflammation J:199407
intestinal inflammation J:199407
Rc3h1m1Btlr/Rc3h1+
C57BL/6J-Rc3h1m1Btlr
decreased body weight J:234246
Rc3h1m1Btlr/Rc3h1m1Btlr
C57BL/6J-Rc3h1m1Btlr
curly tail J:234246
decreased body weight J:234246
Rc3h1san/Rc3h1+
involves: C57BL/6JSfdAnu
abnormal lymph node germinal center morphology J:189087
abnormal lymph node morphology J:189087
abnormal T follicular helper cell physiology J:189087
enlarged lymph nodes J:189087
increased IgG level J:189087
increased spleen weight J:189087
increased T cell derived lymphoma incidence J:189087
increased T follicular helper cell number J:189087
Rc3h1san/Rc3h1san
either: C57BL/6JSfdAnu-Rc3h1san/Anu or (involves: C57BL/6JSfdAnu * CBA/Ca)
abnormal T cell differentiation J:98938
anemia J:98938
enlarged lymph nodes J:98938
glomerulonephritis J:98938
increased anti-double stranded DNA antibody level J:98938
increased anti-nuclear antigen antibody level J:98938
liver inflammation J:98938
thrombocytopenia J:98938
Rc3h1san/Rc3h1san
involves: C57BL/6JSfdAnu
abnormal effector T cell morphology J:199407
abnormal intraepithelial T cell number J:199407
abnormal small intestinal villus morphology J:199407
abnormal small intestine crypts of Lieberkuhn morphology J:199407
cecum inflammation J:199407
chronic liver inflammation J:199407
colitis J:199407
crypts of Lieberkuhn abscesses J:199407
decreased body weight J:199407
enlarged spleen J:199407
granulomatous inflammation J:199407
hepatic necrosis J:199407
ileum inflammation J:199407
increased activated T cell number J:199407
increased CD4-positive, alpha-beta T cell number J:199407
increased circulating tumor necrosis factor level J:196137
increased T cell proliferation J:199407
intestinal ulcer J:199407
lymphoid hyperplasia J:199407
small intestinal inflammation J:199407
Rc3h1tm1.1Mass/Rc3h1tm1.1Mass
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL
abnormal effector T cell morphology J:177784
enlarged spleen J:177784
increased B cell number J:177784
increased eosinophil cell number J:177784
increased regulatory T cell number J:177784
increased spleen weight J:177784
Rc3h1tm1.1Mass/Rc3h1tm1.1Mass
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
abnormal B cell differentiation J:177784
abnormal effector T cell morphology J:177784
abnormal germinal center B cell physiology J:177784
abnormal spleen B cell follicle morphology J:177784
decreased B cell number J:177784
decreased bone marrow cell number J:177784
decreased IgA level J:177784
decreased IgG1 level J:177784
decreased IgG3 level J:177784
decreased immature B cell number J:177784
enlarged spleen J:177784
normal immune system phenotype J:177784
increased eosinophil cell number J:177784
increased IgG2b level J:177784
increased macrophage cell number J:177784
increased regulatory T cell number J:177784
increased spleen weight J:177784
increased splenocyte number J:177784
spleen hyperplasia J:177784
Rc3h1tm1.1Mass/Rc3h1tm1.1Mass
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 * NZB * SJL
normal immune system phenotype J:177784
increased CD8-positive, alpha-beta T cell number J:177784
increased eosinophil cell number J:177784
increased macrophage cell number J:177784
Rc3h1tm1.2Cgv/Rc3h1san
involves: C57BL/6 * C57BL/6JSfdAnu
increased CD4-positive, alpha-beta T cell number J:196137
increased T follicular helper cell number J:196137
Rc3h1tm1.2Cgv/Rc3h1tm1.2Cgv
involves: C57BL/6
abnormal lung development J:196137
abnormal neural tube closure J:196137
perinatal lethality, complete penetrance J:196137
Rc3h1tm1.2Mass/Rc3h1tm1.2Mass
involves: C57BL/6 * CBA * CD-1 * NZB * SJL
abnormal effector T cell morphology J:177784
curly tail J:177784
decreased body weight J:177784
enlarged spleen J:177784
normal immune system phenotype J:177784
increased spleen weight J:177784
postnatal growth retardation J:177784
preweaning lethality, incomplete penetrance J:177784
Rc3h1tm1.2Mass/Rc3h1tm1.2Mass
involves: C57BL/6 * CBA * NZB * SJL
abnormal thymus development J:177784
abnormal vertebral column morphology J:177784
curly tail J:177784
neonatal lethality, complete penetrance J:177784
primary atelectasis J:177784

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory