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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Polr3a
polymerase (RNA) III (DNA directed) polypeptide A
MGI:2681836
33 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Polr3aem2(IMPC)Tcp/Polr3a+
C57BL/6NCrl-Polr3aem2(IMPC)Tcp/Tcp 		enlarged lymph nodes J:211773
enlarged urinary bladder J:211773
increased bone mineral content J:211773
increased mean platelet volume J:211773
Polr3aem2(IMPC)Tcp/Polr3aem2(IMPC)Tcp
C57BL/6NCrl-Polr3aem2(IMPC)Tcp/Tcp 		embryonic lethality prior to organogenesis J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Polr3aGt(LG04)Osb/Polr3aGt(LG04)Osb
B6;D2-Polr3aGt(LG04)Osb/OsbRbrc 		embryonic lethality, complete penetrance J:250577
Polr3aGt(LG04)Osb/Polr3atm1Bebr
involves: C57BL/6 * C57BL/6J * DBA/2 		abnormal gait J:250577
normal nervous system phenotype J:250577
Polr3atm1.1Bebr/Polr3atm1.1Bebr
involves: C57BL/6J 		abnormal gait J:250577
normal nervous system phenotype J:250577
Polr3atm1.1Iwil/Polr3atm1.1Iwil
involves: C57BL/6J 		embryonic lethality, complete penetrance J:311745
Polr3atm1Iwil/Polr3atm1Iwil
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal brain white matter morphology J:311745
abnormal object recognition memory J:311745
abnormal oligodendrocyte physiology J:311745
abnormal spatial reference memory J:311745
decreased body size J:311745
decreased body weight J:311745
decreased myelin sheath thickness J:311745
decreased oligodendrocyte number J:311745
decreased startle reflex J:311745
dysmyelination J:311745
increased thermal nociceptive threshold J:311745
motor developmental delay J:311745
slow postnatal weight gain J:311745
Polr3atm1Iwil/Polr3atm1Iwil
Tg(CAG-cre/Esr1*)5Amc/0
Not Specified 		abnormal emotion/affect behavior J:364909
decreased abdominal adipose tissue amount J:364909
decreased body size J:364909
decreased body weight J:364909
decreased grooming behavior J:364909
decreased locomotor activity J:364909
decreased oligodendrocyte number J:364909
decreased subcutaneous adipose tissue amount J:364909
decreased vertical activity J:364909
dysmyelination J:364909
exocrine pancreas atrophy J:364909
normal homeostasis/metabolism phenotype J:364909
increased microglial cell activation J:364909
neurodegeneration J:364909
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory