Polr3atm1.1Iwil
Targeted Allele Detail
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Symbol: |
Polr3atm1.1Iwil |
Name: |
polymerase (RNA) III (DNA directed) polypeptide A; targeted mutation 1.1, Ian M Willis |
MGI ID: |
MGI:8187814 |
Synonyms: |
Polr3aKI |
Gene: |
Polr3a Location: Chr14:24498764-24537126 bp, - strand Genetic Position: Chr14, 14.4 cM
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Alliance: |
Polr3atm1.1Iwil page
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Germline Transmission: |
Earliest citation of germline transmission:
J:311745
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Humanized sequence) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: A loxP-flanked Polr3a cDNA encoding wild-type exons 15 to 31 and a downstream heterologous polyadenylation signal, followed by intronic sequences and mutant exon 15 encoding the leukodystrophy mutations W671R and G672E were inserted downstream of exon 14. Cre-mediated recombination removed the floxed wild-type exons 15-31, leaving the mutant exon 15.
(J:311745)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Polr3a Mutation: |
70 strains or lines available
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Original: |
J:311745 Merheb E, et al., Defective myelination in an RNA polymerase III mutant leukodystrophic mouse. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2024378118 |
All: |
1 reference(s) |
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