Mir122 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mir122
microRNA 122
MGI:2676805

31 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mir122^tm1.1Apts/Mir122^tm1.1Apts involves: 129 * C57BL/6	abnormal Ito cell morphology	J:190066
	abnormal liver morphology	J:190066
	decreased circulating cholesterol level	J:190066
	decreased circulating HDL cholesterol level	J:190066
	decreased circulating triglyceride level	J:190066
	decreased circulating VLDL cholesterol level	J:190066
	decreased liver glycogen level	J:190066
	hepatic steatosis	J:190066
	increased circulating alanine transaminase level	J:190066
	increased circulating alkaline phosphatase level	J:190066
	increased circulating interleukin-6 level	J:190066
	increased hepatocellular carcinoma incidence	J:190066
	increased liver cholesterol level	J:190066
	increased liver triglyceride level	J:190066
	increased macrophage cell number	J:190066
	increased monocyte cell number	J:190066
	liver fibrosis	J:190066
	liver inflammation	J:190066
Mir122^tm1.1Kgh/Mir122⁺ involves: 129S1/Sv * 129X1/SvJ	increased hepatocellular carcinoma incidence	J:190067
Mir122^tm1.1Kgh/Mir122^tm1.1Kgh involves: 129S1/Sv * 129X1/SvJ	abnormal circulating enzyme level	J:190067
	decreased circulating cholesterol level	J:190067
	decreased circulating HDL cholesterol level	J:190067
	hepatic steatosis	J:190067
	increased bile salt level	J:190067
	increased circulating alanine transaminase level	J:190067
	increased circulating alkaline phosphatase level	J:190067
	increased circulating interleukin-6 level	J:190067
	increased hepatocellular carcinoma incidence	J:190067
	increased liver triglyceride level	J:190067
	increased tumor growth/size	J:190067
	liver fibrosis	J:190067
	liver inflammation	J:190067
Mir122^tm1.2Kgh/Mir122⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	increased hepatocellular carcinoma incidence	J:190067
Mir122^tm1.2Kgh/Mir122^tm1.2Kgh Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	abnormal circulating enzyme level	J:190067
	abnormal lipid homeostasis	J:190067
	abnormal liver physiology	J:190067
	abnormal oval cell physiology	J:190067
	bile duct proliferation	J:190067
	decreased circulating cholesterol level	J:190067
	decreased circulating HDL cholesterol level	J:190067
	decreased circulating LDL cholesterol level	J:190067
	decreased liver glycogen level	J:190067
	increased bile salt level	J:190067
	increased circulating alanine transaminase level	J:190067
	increased circulating alkaline phosphatase level	J:190067
	increased circulating interleukin-6 level	J:190067
	increased hepatocellular carcinoma incidence	J:190067
	increased interleukin-6 secretion	J:190067
	increased liver triglyceride level	J:190067
	increased liver tumor incidence	J:190067
	increased monocyte cell number	J:190067
	increased neutrophil cell number	J:190067
	increased tumor necrosis factor secretion	J:190067
	liver fibrosis	J:190067
	liver inflammation	J:190067
	microvesicular hepatic steatosis	J:190067

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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