P2ry6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
MGI:2673874

14 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
P2ry6^tm1.1Brob/P2ry6^tm1.1Brob involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal macrophage physiology	J:169742
	decreased vasoconstriction	J:169742
	decreased vasodilation	J:169742
P2ry6^tm1Jabo/P2ry6^tm1Jabo Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ B6.Cg-Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} P2ry6^tm1Jabo	abnormal respiratory mucosa goblet cell morphology	J:179177
	increased eosinophil cell number	J:179177
	increased interferon-gamma secretion	J:179177
	increased interleukin-4 secretion	J:179177
	increased interleukin-5 secretion	J:179177
	increased interleukin-13 secretion	J:179177
	increased neutrophil cell number	J:179177
	lung inflammation	J:179177
P2ry6^tm1Jabo/P2ry6^tm1Jabo Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ involves: 129 * C57BL/6 * C57BL/6NTac	abnormal respiratory mucosa goblet cell morphology	J:179177
	decreased IgE level	J:179177
	decreased T cell apoptosis	J:179177
	increased eosinophil cell number	J:179177
	increased interferon-gamma secretion	J:179177
	increased interleukin-4 secretion	J:179177
	increased interleukin-5 secretion	J:179177
	increased interleukin-13 secretion	J:179177
	increased neutrophil cell number	J:179177
	increased T cell proliferation	J:179177
	lung inflammation	J:179177

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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