Pi4ka Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pi4ka
phosphatidylinositol 4-kinase alpha
MGI:2448506

36 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pi4ka^m1Btlr/Pi4ka^m1Btlr C57BL/6J-Pi4ka^m1Btlr	decreased macrophage apoptosis	J:265261
	decreased tumor necrosis factor secretion	J:265261
	increased cell death	J:265261
	increased interleukin-1 beta secretion	J:265261
Pi4ka^m2Btlr/Pi4ka^m2Btlr C57BL/6J-Pi4ka^m2Btlr	increased alpha-beta T cell number	J:272852
	increased CD4-positive, alpha-beta T cell number	J:272852
	increased central memory CD4-positive, alpha-beta T cell number	J:272852
Pi4ka^tm1.1Arte/Pi4ka^tm1.1Arte C57BL/6NTac-Pi4ka^tm1.1Arte	no abnormal phenotype detected	J:172497
Pi4ka^tm1.1Arte/Pi4ka^tm1.1Arte Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ involves: C57BL/6NTac	abnormal cecum morphology	J:188779
	abnormal digestive system morphology	J:188779
	abnormal duodenum morphology	J:188779
	abnormal gastric parietal cell morphology	J:188779
	abnormal intestine morphology	J:188779
	abnormal stomach mucosa morphology	J:188779
	distended stomach	J:188779
	premature death	J:188779
Pi4ka^tm1.2Pdc/Pi4ka^tm1.2Pdc involves: 129S1/Sv * C57BL/6 * FVB/N * SJL	embryonic lethality, complete penetrance	J:195235
Pi4ka^{tm1b(EUCOMM)Wtsi}/Pi4ka⁺ C57BL/6N-Pi4ka^{tm1b(EUCOMM)Wtsi}/Tcp	increased erythrocyte cell number	J:211773
	increased hematocrit	J:211773
	increased monocyte cell number	J:211773
	limb grasping	J:211773
Pi4ka^{tm1b(EUCOMM)Wtsi}/Pi4ka^{tm1b(EUCOMM)Wtsi} C57BL/6N-Pi4ka^{tm1b(EUCOMM)Wtsi}/Tcp	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Pi4ka^tm2.1Arte/Pi4ka⁺ Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ involves: C57BL/6NTac	abnormal coat appearance	J:188779
	abnormal digestive system morphology	J:188779
	abnormal spleen morphology	J:188779
	decreased body weight	J:188779
	hunched posture	J:188779
	premature death	J:188779
Pi4ka^tm2.1Arte/Pi4ka^tm2.1Arte involves: C57BL/6 * C57BL/6NTac	no abnormal phenotype detected	J:172498
Pi4ka^tm2.1Arte/Pi4ka^tm2.1Arte Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ involves: C57BL/6NTac	abnormal coat appearance	J:188779
	abnormal digestion	J:188779
	abnormal digestive system morphology	J:188779
	abnormal large intestine crypts of Lieberkuhn morphology	J:188779
	abnormal large intestine morphology	J:188779
	abnormal small intestinal villus morphology	J:188779
	abnormal small intestine crypts of Lieberkuhn morphology	J:188779
	decreased body size	J:188779
	diarrhea	J:188779
	hunched posture	J:188779
	premature death	J:188779
	unresponsive to tactile stimuli	J:188779

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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