Pi4ka^tm1.2Pdc
Targeted Allele Detail

Summary

• Symbol: Pi4ka^tm1.2Pdc
• Name: phosphatidylinositol 4-kinase alpha; targeted mutation 1.2, Pietro De Camilli
• MGI ID: MGI:5478563
• Gene: Pi4ka Location: Chr16:17098215-17224178 bp, - strand Genetic Position: Chr16, 10.71 cM
• Alliance: Pi4ka^tm1.2Pdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195235
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J x 129S1/Sv

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 48. An additional loxP site was inserted downstream of exon 52. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed exons 48 through 52. (J:195235)

Generation of the Pi4ka^tm1.1Pdc and Pi4ka^tm1.2Pdc alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pi4ka Mutation: 129 strains or lines available

References

• Original: J:195235 Nakatsu F, et al., PtdIns4P synthesis by PI4KIIIalpha at the plasma membrane and its impact on plasma membrane identity. J Cell Biol. 2012 Dec 10;199(6):1003-16
• All: 1 reference(s)