Dhtkd1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dhtkd1
dehydrogenase E1 and transketolase domain containing 1
MGI:2445096

40 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dhtkd1^em1Hpr/Dhtkd1^em1Hpr involves: C57BL/6N * FVB/N	abnormal amino acid metabolism	J:256227
Dhtkd1^em1Hpr/Dhtkd1^em1Hpr involves: C57BL/6N * FVB/N	normal behavior/neurological phenotype	J:256227
Dhtkd1^tm1Mmgu/Dhtkd1⁺ involves: 129S6/SvEvTac * C57BL/6J	abnormal axon morphology	J:288186
	axon degeneration	J:288186
	decreased myelin sheath thickness	J:288186
	tomacula	J:288186
Dhtkd1^tm1Mmgu/Dhtkd1^tm1Mmgu involves: 129S6/SvEvTac * C57BL/6J	abnormal axon morphology	J:288186
	abnormal gastrocnemius morphology	J:288186
	abnormal myelination	J:288186
	axon degeneration	J:288186
	decreased circulating cholesterol level	J:288186
	decreased circulating glycerol level	J:288186
	decreased circulating triglyceride level	J:288186
	decreased myelin sheath thickness	J:288186
	increased circulating phospholipid level	J:288186
	increased mitochondrial number	J:288186
	increased mitochondrial size	J:288186
	increased respiratory quotient	J:288186
	increased thermal nociceptive threshold	J:288186
	tomacula	J:288186
Dhtkd1^tm1Zgwg/Dhtkd1^tm1Zgwg involves: C57BL/6	abnormal motor capabilities/coordination/movement	J:267178
	abnormal myelin sheath morphology	J:267178
	abnormal nervous system morphology	J:267178
	abnormal neuromuscular synapse morphology	J:267178
	abnormal pancreatic islet morphology	J:267178
	abnormal sarcomere morphology	J:267178
	abnormal Schwann cell physiology	J:267178
	abnormal sciatic nerve morphology	J:267178
	aciduria	J:267178
	axon degeneration	J:267178
	decreased circulating glucose level	J:267178
	decreased nerve conduction velocity	J:267178
	demyelination	J:267178
	impaired exercise endurance	J:267178
	improved glucose tolerance	J:267178
	increased circulating creatine kinase level	J:267178
	increased circulating insulin level	J:267178
	increased circulating insulin-like growth factor I level	J:267178
	increased circulating lactate dehydrogenase level	J:267178
	increased insulin secretion	J:267178
	increased insulin sensitivity	J:267178
	increased liver glycogen level	J:267178
	increased Schwann cell number	J:267178
	increased thermal nociceptive threshold	J:267178
	muscular atrophy	J:267178
	progressive muscle weakness	J:267178

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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