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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hif1an
hypoxia-inducible factor 1, alpha subunit inhibitor
MGI:2442345
49 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hif1anem1(IMPC)Mbp/Hif1anem1(IMPC)Mbp
C57BL/6N-Hif1anem1(IMPC)Mbp/MbpMmucd 		abnormal bone structure J:211773
abnormal coat/hair pigmentation J:211773
abnormal eye morphology J:211773
abnormal kidney morphology J:211773
abnormal liver morphology J:211773
abnormal skin morphology J:211773
abnormal spleen morphology J:211773
decreased exploration in new environment J:211773
decreased prepulse inhibition J:211773
enlarged kidney J:211773
enlarged spleen J:211773
increased neutrophil cell number J:211773
increased startle reflex J:211773
preweaning lethality, incomplete penetrance J:211773
prolonged QRS complex duration J:211773
small liver J:211773
Hif1antm1.1Rsjo/Hif1antm1.1Rsjo
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129 * C57BL/6 * DBA 		no abnormal phenotype detected J:160941
Hif1antm1.1Rsjo/Hif1antm1.1Rsjo
Tg(Nes-cre)1Wme/0
involves: 129 * C57BL/6 * CBA 		decreased circulating insulin level J:160941
decreased susceptibility to weight gain J:160941
increased insulin sensitivity J:160941
Hif1antm1.2Rsjo/Hif1antm1.2Rsjo
B6.129-Hif1antm1.2Rsjo 		abnormal cell physiology J:160941
abnormal circulating hormone level J:160941
abnormal lung volume J:160941
abnormal oxygen level J:160941
alkalosis J:160941
decreased body weight J:160941
decreased circulating cholesterol level J:160941
decreased circulating glucose level J:160941
decreased circulating HDL cholesterol level J:160941
decreased circulating insulin level J:160941
decreased circulating LDL cholesterol level J:160941
decreased circulating triglyceride level J:160941
decreased circulating VLDL triglyceride level J:160941
decreased epididymal fat pad weight J:160941
decreased liver triglyceride level J:160941
decreased liver weight J:160941
decreased locomotor activity J:160941
decreased quadriceps weight J:160941
decreased susceptibility to diet-induced hepatic steatosis J:160941
decreased susceptibility to weight gain J:160941
decreased white fat cell size J:160941
hypocapnia J:160941
increased basal metabolism J:160941
increased carbon dioxide production J:160941
increased circulating cholesterol level J:160941
increased fluid intake J:160941
increased food intake J:160941
increased heart rate J:160941
increased insulin sensitivity J:160941
increased oxygen consumption J:160941
increased pulmonary respiratory rate J:160941
increased tidal volume J:160941
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory