Gak Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gak
cyclin G associated kinase
MGI:2442153

30 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gak^tm1Legr/Gak^tm1Legr involves: 129S6/SvEvTac * C57BL/6	embryonic lethality, complete penetrance	J:180119
Gak^tm1Noj/Gak^tm1Noj C57BL/6-Gak^tm1Noj	abnormal lung alveolus development	J:179585
	abnormal pulmonary alveolar sac morphology	J:179585
	abnormal pulmonary interalveolar septum morphology	J:179585
	abnormal surfactant physiology	J:179585
	normal cellular phenotype	J:179585
	neonatal lethality, complete penetrance	J:179585
Gak^tm2Legr/Gak^tm2Legr involves: 129S6/SvEvTac * C57BL/6	no abnormal phenotype detected	J:180119
Gak^tm2Legr/Gak^tm2Legr involves: 129S6/SvEvTac * C57BL/6	abnormal plasma membrane morphology	J:180119
Gak^tm2Legr/Gak^tm2Legr Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S6/SvEvTac * C57BL/6 * DBA	abnormal bile duct morphology	J:180119
	abnormal hepatoblast differentiation	J:180119
	abnormal liver morphology	J:180119
	decreased body size	J:180119
	decreased liver glycogen level	J:180119
	increased body weight	J:180119
	jaundice	J:180119
	postnatal lethality, complete penetrance	J:180119
Gak^tm2Legr/Gak^tm2Legr Tg(CAG-cre/Esr1)5Amc/0 involves: 129S6/SvEvTac C57BL/6 * CBA	premature death	J:180119
Gak^tm2Legr/Gak^tm2Legr Tg(KRT14-cre)1Amc/0 involves: 129S6/SvEvTac * C57BL/6 * CBA	abnormal epidermal layer morphology	J:180119
	abnormal epidermis stratum corneum morphology	J:180119
	dehydration	J:180119
	impaired skin barrier function	J:180119
	postnatal lethality, complete penetrance	J:180119
	wrinkled skin	J:180119
Gak^tm2Legr/Gak^tm2Legr Tg(Nes-cre)1Kln/0 involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal Ammon gyrus morphology	J:180119
	abnormal cortical ventricular zone morphology	J:180119
	abnormal dentate gyrus morphology	J:180119
	abnormal neuron differentiation	J:180119
	abnormal neuronal precursor proliferation	J:180119
	decreased neuronal precursor cell number	J:180119
	lethargy	J:180119
	postnatal lethality, complete penetrance	J:180119

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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