Gys2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gys2
glycogen synthase 2
MGI:2385254

28 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gys2^m1Btlr/Gys2^m1Btlr C57BL/6J-Gys2^m1Btlr	decreased fasting circulating glucose level	J:265256
Gys2^m2Btlr/Gys2^m2Btlr C57BL/6J-Gys2^m2Btlr	decreased fasting circulating glucose level	J:265257
Gys2^m3Btlr/Gys2^m3Btlr C57BL/6J-Gys2^m3Btlr	impaired glucose tolerance	J:265258
Gys2^tm1.1Arte/Gys2⁺ Not Specified	abnormal hepatocyte physiology	J:208923
	decreased glycogen catabolism rate	J:208923
	normal homeostasis/metabolism phenotype	J:208923
	impaired glucose tolerance	J:208923
	increased liver triglyceride level	J:208923
Gys2^tm1.1Arte/Gys2^tm1.1Arte Not Specified	abnormal gluconeogenesis	J:208923
	abnormal glucose homeostasis	J:208923
	abnormal hepatocyte physiology	J:208923
	decreased circulating glucose level	J:208923
	decreased circulating insulin level	J:208923
	decreased glycogen catabolism rate	J:208923
	decreased liver glycogen level	J:208923
	impaired glucose tolerance	J:208923
	increased liver triglyceride level	J:208923
	insulin resistance	J:208923
Gys2^tm1.1Pro/Gys2^tm1.1Pro Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA	abnormal circulating ketone body level	J:162043
	abnormal gluconeogenesis	J:162043
	abnormal glucose homeostasis	J:162043
	abnormal triglyceride level	J:162043
	decreased cardiac muscle cell glucose uptake	J:162043
	decreased circulating glucose level	J:162043
	decreased circulating insulin level	J:162043
	decreased glycogen catabolism rate	J:162043
	decreased glycogen level	J:162043
	decreased heart weight	J:162043
	decreased liver weight	J:162043
	decreased systemic arterial diastolic blood pressure	J:162043
	impaired exercise endurance	J:162043
	impaired glucose tolerance	J:162043
	increased liver triglyceride level	J:162043
Gys2^{tm1a(KOMP)Wtsi}/Gys2⁺ B6J.B6N-Gys2^{tm1a(KOMP)Wtsi}	normal liver/biliary system phenotype	J:208923
Gys2^{tm1a(KOMP)Wtsi}/Gys2^{tm1a(KOMP)Wtsi} B6J.B6N-Gys2^{tm1a(KOMP)Wtsi}	decreased liver glycogen level	J:208923
Gys2^{tm1a(KOMP)Wtsi}/Gys2^{tm1a(KOMP)Wtsi} B6JTyr;B6N-Gys2^{tm1a(KOMP)Wtsi}/Wtsi	abnormal vibrissa morphology	J:175295
	decreased body weight	J:165965
	decreased circulating glucose level	J:165965, J:175295
	decreased circulating glycerol level	J:175295
	increased circulating calcium level	J:165965
	increased circulating chloride level	J:165965
	increased circulating sodium level	J:165965
	increased circulating total protein level	J:165965

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23