Elmo1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Elmo1
engulfment and cell motility 1
MGI:2153044

27 phenotypes from 7 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Elmo1^M1Btlr/Elmo1^M1Btlr C57BL/6J-Elmo1^M1Btlr	decreased B cell number	J:265231
	decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:265231
	decreased IgM level	J:265231
	impaired humoral immune response	J:265231
	increased B-1 B cell number	J:265231
	increased CD8-positive, alpha-beta memory T cell number	J:265231
Elmo1^m2Btlr/Elmo1^m2Btlr C57BL/6J-Elmo1^m2Btlr	decreased B cell number	J:265232
Elmo1^m3Btlr/Elmo1^m3Btlr C57BL/6J-Elmo1^m3Btlr	decreased central memory CD8 positive, alpha-beta T cell number	J:271894
	decreased NK cell number	J:271894
	increased CD8-positive, alpha-beta T cell number	J:271894
Elmo1^M4Btlr/Elmo1^M4Btlr C57BL/6J-Elmo1^M4Btlr	abnormal B cell morphology	J:271969
	abnormal T cell morphology	J:271969
	decreased CD4-positive, alpha-beta T cell number	J:271969
	increased B-1 B cell number	J:271969
	increased CD8-positive, alpha-beta T cell number	J:271969
Elmo1^tm1.1Ravi/Elmo1^tm1.1Ravi Tg(Amh-cre)8815Reb/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	abnormal seminiferous tubule morphology	J:164662
	increased male germ cell apoptosis	J:164662
	oligozoospermia	J:164662
Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal male germ cell apoptosis	J:164662
	abnormal seminiferous tubule epithelium morphology	J:164662
	abnormal seminiferous tubule morphology	J:164662
	abnormal Sertoli cell morphology	J:164662
	abnormal testis morphology	J:164662
	decreased Sertoli cell phagocytosis	J:164662
	multinucleated giant male germ cells	J:164662
Elmo1^{tm1a(EUCOMM)Wtsi}/Elmo1^{tm1a(EUCOMM)Wtsi} C57BL/6N-Elmo1^{tm1a(EUCOMM)Wtsi}/Wtsi	decreased fasting circulating glucose level	J:211773
	increased grip strength	J:211773
	increased lean body mass	J:211773
	increased leukocyte cell number	J:211773
	increased mean corpuscular hemoglobin	J:211773
	increased red blood cell distribution width	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23