Elmo1^tm1.1Ravi
Targeted Allele Detail

Summary

• Symbol: Elmo1^tm1.1Ravi
• Name: engulfment and cell motility 1; targeted mutation 1.1, Kodi S Ravichandran
• MGI ID: MGI:4838426
• Synonyms: Elmo1^F
• Gene: Elmo1 Location: Chr13:20274766-20792523 bp, + strand Genetic Position: Chr13, 7.21 cM, cytoband A3.1
• Alliance: Elmo1^tm1.1Ravi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164662
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette with a 3' loxP site was inserted upstream of exon 5, and a loxP site was inserted downstream of exon 5. Flp mediated recombination removed the neo cassette leaving exon 5 floxed. (J:164662)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elmo1 Mutation: 58 strains or lines available

References

• Original: J:164662 Elliott MR, et al., Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo. Nature. 2010 Sep 16;467(7313):333-7
• All: 3 reference(s)