Dot1l Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dot1l
DOT1 like histone lysine methyltransferase
MGI:2143886

49 phenotypes from 9 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dot1l^{Gt(RRR032)Byg}/Dot1l^{Gt(RRR032)Byg} involves: 129P2/OlaHsd	prenatal lethality, complete penetrance	J:133922
Dot1l^tm1.1Saam/Dot1l^tm1.1Saam involves: 129S1/Sv * C57BL/6	no abnormal phenotype detected	J:193161
Dot1l^tm1.1Saam/Dot1l^tm1.1Saam involves: 129S1/Sv * C57BL/6	abnormal bone marrow cell morphology/development	J:193161
	abnormal bone marrow cell physiology	J:193161
	decreased tumor growth/size	J:193161
Dot1l^tm1.1Saam/Dot1l^tm1.1Saam Tg(VAV1-cre)1Graf/0 involves: 129S1/Sv * C57BL/6	abnormal definitive hematopoiesis	J:193161
	abnormal leukopoiesis	J:193161
	anemia	J:193161
	decreased bone marrow cell number	J:193161
	decreased common myeloid progenitor cell number	J:193161
	decreased hematopoietic stem cell number	J:193161
	decreased lymphocyte cell number	J:193161
	decreased neutrophil cell number	J:193161
	impaired hematopoiesis	J:193161
Dot1l^tm1.1Tche/Dot1l^tm1.1Tche either: (involves: C57BL/6) or (involves: 129/Sv * C57BL/6)	abnormal cell physiology	J:161427
	abnormal vitelline vasculature morphology	J:161427
	aneuploidy	J:161427
	decreased cell proliferation	J:161427
	decreased embryo size	J:161427
	embryonic growth retardation	J:161427
	embryonic lethality during organogenesis, complete penetrance	J:161427
	enlarged heart	J:161427
	increased embryonic tissue cell apoptosis	J:161427
	increased telomere length	J:161427
	short tail	J:161427
Dot1l^tm1.1Wezh/Dot1l^tm1.1Wezh B6(SJL)-Dot1l^tm1.1Wezh	no abnormal phenotype detected	J:194304
Dot1l^tm1.2Wezh/Dot1l^tm1.2Wezh involves: C57BL/6 * C57BL/6J * CBA * SJL	preweaning lethality, complete penetrance	J:194304
Dot1l^{tm1a(KOMP)Wtsi}/Dot1l⁺ Not Specified	abnormal behavior	J:175295
Dot1l^{tm1c(KOMP)Wtsi}/Dot1l^{tm1c(KOMP)Wtsi} Tg(Col2a1-cre)1Bhr/0 involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * SJL	abnormal articular cartilage morphology	J:246059
	abnormal long bone epiphyseal plate morphology	J:246059
	abnormal long bone epiphyseal plate proliferative zone	J:246059
	postnatal growth retardation	J:246059
Dot1l^tm1Tche/Dot1l^tm1.1Tche Tg(Myhca-cre)1Abel/0 Not Specified	abnormal heart morphology	J:168140
	abnormal muscle physiology	J:168140
	atrioventricular block	J:168140
	cardiac interstitial fibrosis	J:168140
	decreased cardiac output	J:168140
	dilated cardiomyopathy	J:168140
	dilated heart ventricle	J:168140
	enlarged heart	J:168140
	heart block	J:168140
	increased cardiomyocyte apoptosis	J:168140
	increased fetal cardiomyocyte proliferation	J:168140
	increased heart left ventricle size	J:168140
	increased heart weight	J:168140
	postnatal lethality, incomplete penetrance	J:168140
	premature death	J:168140
	prolonged P wave	J:168140
	prolonged PR interval	J:168140
	prolonged QRS complex duration	J:168140
	prolonged RR interval	J:168140
Dot1l^tm1Wezh/Dot1l^tm1Wezh C57BL/6J-Dot1l^tm1Wezh	no abnormal phenotype detected	J:194304

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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