Dot1l^tm1.2Wezh
Targeted Allele Detail

Summary

• Symbol: Dot1l^tm1.2Wezh
• Name: DOT1 like histone lysine methyltransferase; targeted mutation 1.2, Wenzheng Zhang
• MGI ID: MGI:5471957
• Synonyms: Dot1l^delta
• Gene: Dot1l Location: Chr10:80591040-80631295 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Dot1l^tm1.2Wezh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194304
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette and left exon 5 floxed. Cre-mediated recombination removed the exon 5. (J:194304)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dot1l Mutation: 75 strains or lines available

References

• Original: J:194304 Chang MJ, et al., Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes. Cancer Res. 2010 Dec 15;70(24):10234-42
• All: 1 reference(s)