Dot1ltm1c(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Dot1ltm1c(KOMP)Wtsi |
Name: |
DOT1 like histone lysine methyltransferase; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5925348 |
Synonyms: |
Dot1lfl |
Gene: |
Dot1l Location: Chr10:80591040-80631295 bp, + strand Genetic Position: Chr10, 39.72 cM
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Alliance: |
Dot1ltm1c(KOMP)Wtsi page
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IMPC: |
Dot1l gene page |
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Mutant Cell Line: |
EPD0018_2_D02 |
Germline Transmission: |
Earliest citation of germline transmission:
J:246059
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Parent Cell Line: |
JM8 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
Vector: L1L2_gtk
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Mutation details: The L1L2_gtk cassette was inserted at position 80599973 of Chromosome 10 upstream of the critical exon 2 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of exon 2 at position 80600773. Exon 2 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving exon 2 flanked by loxP sites.
(J:246059)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:246059 Monteagudo S, et al., DOT1L safeguards cartilage homeostasis and protects against osteoarthritis. Nat Commun. 2017 Jun 19;8:15889 |
All: |
22 reference(s) |
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