Cdk5rap3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdk5rap3
CDK5 regulatory subunit associated protein 3
MGI:1933126

39 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdk5rap3^{tm1b(EUCOMM)Hmgu}/Cdk5rap3⁺ C57BL/6N-Cdk5rap3^{tm1b(EUCOMM)Hmgu}/Ieg	abnormal lens morphology	J:211773
	abnormal retina blood vessel morphology	J:211773
	abnormal retina morphology	J:211773
	abnormal retina vasculature morphology	J:211773
	abnormal vitreous body morphology	J:211773
	cataract	J:211773
	decreased cardiac stroke volume	J:211773
	decreased exploration in new environment	J:211773
	increased fasting circulating glucose level	J:211773
	persistence of hyaloid vascular system	J:211773
Cdk5rap3^{tm1b(EUCOMM)Hmgu}/Cdk5rap3^{tm1b(EUCOMM)Hmgu} C57BL/6N-Cdk5rap3^{tm1b(EUCOMM)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773
Cdk5rap3^{tm1b(EUCOMM)Hmgu}/Cdk5rap3^{tm1b(EUCOMM)Hmgu} involves: C57BL/6N * FVB/N	abnormal cholangiocyte morphology	J:272566
	abnormal erythropoiesis	J:272566
	abnormal hepatoblast differentiation	J:272566
	abnormal liver physiology	J:272566
	anemia	J:272566
	decreased hematopoietic stem cell number	J:272566
	decreased hepatocyte proliferation	J:272566
	decreased liver weight	J:272566
	fetal growth retardation	J:272566
	hemorrhage	J:272566
	increased nucleated erythrocyte cell number	J:272566
	lethality during fetal growth through weaning, complete penetrance	J:272566
	liver hypoplasia	J:272566
	small liver	J:272566
Cdk5rap3^{tm1c(EUCOMM)Hmgu}/Cdk5rap3^{tm1c(EUCOMM)Hmgu} Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ involves: 129S4/SvJaeSor * C57BL/6N * C57BL/10 * CBA/Ca	abnormal hemopoiesis	J:272566
	normal mortality/aging	J:272566
Cdk5rap3^{tm1c(EUCOMM)Hmgu}/Cdk5rap3^{tm1c(EUCOMM)Hmgu} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S4/SvJaeSor * C57BL/6N * DBA	normal liver/biliary system phenotype	J:272566
	normal mortality/aging	J:272566
Cdk5rap3^{tm1c(EUCOMM)Hmgu}/Cdk5rap3^{tm1c(EUCOMM)Hmgu} Tg(Foxa3-cre)1Khk/0 involves: 129S4/SvJaeSor * C57BL/6N * DBA	abnormal hepatic cord morphology	J:272566
	abnormal hepatocyte morphology	J:272566
	abnormal hepatocyte physiology	J:272566
	decreased body weight	J:272566
	decreased circulating cholesterol level	J:272566
	decreased circulating triglyceride level	J:272566
	decreased fasting circulating glucose level	J:272566
	decreased liver weight	J:272566
	hypoglycemia	J:272566
	increased circulating alanine transaminase level	J:272566
	increased circulating bilirubin level	J:272566
	liver hypoplasia	J:272566
	premature death	J:272566
	small liver	J:272566

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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