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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tsc1
TSC complex subunit 1
MGI:1929183
25 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Lin28atm1.1Gqda/\Lin28atm1.1Gqda
\Tsc1tm1.1Djk/\Tsc1+
involves: 129S4/SvJae * C57BL/6 		decreased body size J:199720
neonatal lethality, incomplete penetrance J:199720
\Lin28btm1.1Gqda/\Lin28btm1.1Gqda
\Tsc1tm1.1Djk/\Tsc1+
involves: 129S4/SvJae * C57BL/6 * FVB 		normal growth/size/body region phenotype J:199720
\Lin28btm1Gqda/\Lin28btm1Gqda
\Myf5tm1(cre)Mrc/\Myf5+
\Tsc1tm1Djk/\Tsc1+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		normal growth/size/body region phenotype J:199720
\Mettl1em1Bcgen/\Mettl1em1Bcgen
\Tsc1tm1Djk/\Tsc1tm1Djk
\Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL/J 		abnormal autopod morphology J:355649
decreased bone mineralization J:355649
short limbs J:355649
\Nf1tm1Fcr/\Nf1+
\Tsc1tm1Djk/\Tsc1tm1Djk
\Tg(GFAP-cre)#Gtm/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA 		normal neoplasm J:176586
premature death J:176586
\Pdpk1tm1Maka/\Pdpk1tm1Maka
\Tsc1tm1Djk/\Tsc1tm1Djk
\Tg(Gdf9-icre)5092Coo/?
involves: 129S4/SvJae * C57BL/6J 		abnormal ovarian follicle morphology J:155357
\Ptentm1Hwu/\Ptentm1Hwu
\Tsc1tm1Djk/\Tsc1tm1Djk
\Tg(Gdf9-icre)5092Coo/?
involves: 129S4/SvJae * C57BL/6J 		abnormal ovarian follicle morphology J:155357
\Rhebtm1.1Yelg/\Rheb+
\Tsc1tm1Chdl/\Tsc1tm1Chdl
B6.129P2-Tsc1tm1Chdl Rhebtm1.1Yelg 		decreased fetal size J:170999
fetal growth retardation J:170999
increased embryonic tissue cell apoptosis J:170999
lethality throughout fetal growth and development, complete penetrance J:170999
\Slc38a1tm1.1Ttaka/\Slc38a1tm1.1Ttaka
\Tsc1tm1Djk/\Tsc1+
\Tg(Syn1-cre)671Jxm/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj 		normal nervous system phenotype J:288818
\Trp53tm1Brn/\Trp53tm1Brn
\Tsc1tm1Djk/\Tsc1tm1Djk
involves: 129P2/OlaHsd * 129S4/SvJae 		hemorrhagic ascites J:212578
increased mesothelioma incidence J:212578
premature death J:212578
\Tsc1tm1Djk/\Tsc1tm1Djk
\Gt(ROSA)26Sortm1Sho/\Gt(ROSA)26Sor+
involves: 129S4/SvJae * 129S4/SvJaeSor 		abnormal brain morphology J:221022
abnormal brain ventricle morphology J:221022
abnormal neuron morphology J:221022
abnormal postnatal subventricular zone morphology J:221022
cachexia J:221022
enlarged lateral ventricles J:221022
hunched posture J:221022
hydrocephaly J:221022
increased brain size J:221022
premature death J:221022
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory